hif-1;npr-1

Lifespan changes: From wild type to hif-1;npr-1 / From hif-1;npr-1 to multiple mutants

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Genetic mutants with hif-1, npr-1 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    21

  • Diet

    live OP50

  • Lifespan (days)

    12.23

  • Lifespan change (compared to wild type)

    -16.75%

  • Phenotype

    N2 worms bearing the hif-1(ia4) deletion allele lived significantly longer than N2 controls . By contrast, the deletion of hif-1 shortened the lifespans of npr-1(ad609) mutants to less than that of N2, suggesting that the beneficial effect of HIF-1 on worm lifespan is mediated by NPR-1(215V) activity.

  • Lifespan comparisons

    Double mutant hif-1(ia4);npr-1(ad609) has a lifespan of 12.23 days, while single mutant hif-1(ia4) has a lifespan of 15.48 days, single mutant npr-1(ad609) has a lifespan of 16.03 days and wild type has a lifespan of 14.69 days.

  • Type of interaction
    See methods

    Antagonistic (negative)

  • Citation
    View abstract

    Abergel R et al., 2017, Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell. 16(2):401-413 PubMed 28054425 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    21

  • Diet

    live OP50

  • Lifespan (days)

    11.0

  • Lifespan change (compared to wild type)

    -22.59%

  • Phenotype

    N2 worms bearing the hif-1(ia4) deletion allele lived significantly longer than N2 controls . By contrast, the deletion of hif-1 shortened the lifespans of npr-1(ad609) mutants to less than that of N2, suggesting that the beneficial effect of HIF-1 on worm lifespan is mediated by NPR-1(215V) activity.

  • Lifespan comparisons

    Double mutant hif-1(ia4);npr-1(ad609) has a lifespan of 11.0 days, while single mutant hif-1(ia4) has a lifespan of 17.18 days, single mutant npr-1(ad609) has a lifespan of 18.78 days and wild type has a lifespan of 14.21 days.

  • Type of interaction
    See methods

    Antagonistic (negative)

  • Citation
    View abstract

    Abergel R et al., 2017, Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell. 16(2):401-413 PubMed 28054425 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    21

  • Diet

    live OP50

  • Lifespan (days)

    10.28

  • Lifespan change (compared to wild type)

    -22.53%

  • Phenotype

    N2 worms bearing the hif-1(ia4) deletion allele lived significantly longer than N2 controls . By contrast, the deletion of hif-1 shortened the lifespans of npr-1(ad609) mutants to less than that of N2, suggesting that the beneficial effect of HIF-1 on worm lifespan is mediated by NPR-1(215V) activity.

  • Lifespan comparisons

    Double mutant hif-1(ia4);npr-1(ad609) has a lifespan of 10.28 days, while single mutant hif-1(ia4) has a lifespan of 14.54 days, single mutant npr-1(ad609) has a lifespan of 14.07 days and wild type has a lifespan of 13.27 days.

  • Type of interaction
    See methods

    Antagonistic (negative)

  • Citation
    View abstract

    Abergel R et al., 2017, Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell. 16(2):401-413 PubMed 28054425 Click here to select all mutants from this PubMed ID in the graph

Search genes: hif-1 npr-1
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

HIF (Hypoxia Inducible Factor) homologa;Hypoxia-inducible factor 1

Locus: CELE_F38A6.3

Wormbase description: hif-1 encodes an ortholog of the mammalian hypoxia-induced factor HIF-1, and is required for survival in hypoxic environments (1% oxygen) that have no effect on wild-type C. elegans.

  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

NeuroPeptide Receptor family

Locus: CELE_C39E6.6

Wormbase description: npr-1 encodes a predicted G protein-coupled neuropeptide receptor that is homologous to the mammalian neuropeptide Y (NPY) receptor (OMIM:162641) required for regulating anxiety, food consumption, and pain sensation; in C. elegans, NPR-1 is involved in ethological variations of social behavior such as social versus solitary feeding; in regulating social behavior, NPR-1 functions as a receptor for the FLP-18 and FLP-21 peptide ligands; NPR-1 also affects some aspect of UNC-6/netrin-mediated branching of motor neurons, as strong npr-1 mutations can suppress abnormal migration of ventral nerve cord neurons induced by overexpression of UNC-6 lacking domain C; NPR-1 is expressed predominantly in the nervous system, and particularly in the AQR, PQR, and URX neurons that are exposed to the body fluid.

Orthologs of hif-1;npr-1 in SynergyAge
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Orthologs of hif-1 in SynergyAge
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Orthologs of npr-1 in SynergyAge
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About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Contact
Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania
Email:

Group webpage: www.aging-research.group