Lifespan changes: From wild type to unc-31;unc-64

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Genetic mutants with unc-31, unc-64 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C


  • Lifespan (days)


  • Lifespan change (compared to wild type)


  • Phenotype

    Both the dauer and life span phenotypes of an unc-64; unc-31 double mutant were stronger than those of either single mutant, suggesting that unc-64 and unc-31 are partially redundant

  • Lifespan comparisons

    Double mutant unc-31(e928);unc-64(e246) has a lifespan of 43 days, while single mutant unc-31(e928) has a lifespan of 35 days and wild type has a lifespan of 24 days.

  • Type of interaction
    See methods

    Almost additive (positive)

  • Citation
    View abstract

    Ailion M et al., 1999, Neurosecretory control of aging in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 96(13):7394-7 PubMed 10377425 Click here to select all mutants from this PubMed ID in the graph

Search genes: unc-31 unc-64
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Calcium-dependent secretion activator;hypothetical protein

Locus: CELE_ZK897.1

Wormbase description: unc-31 encodes a pleckstrin homology (PH) domain-containing protein that is the C. elegans ortholog of human CADPS/CAPS (calcium-dependent activator protein for secretion OMIM:604667); UNC-31 functions in post-docking calcium-regulated dense-core vesicle fusion that is required for egg laying, locomotion, pharyngeal pumping, and recovery from the dauer larval stage; in addition, UNC-31 functions in the insulin receptor signaling pathway that regulates adult life span where it may control Ca[2+]-regulated secretion of an insulin-like ligand; UNC-31 is not required for synaptic vesicle exocytosis; unc-31::gfp transcriptional reporters are expressed in most, if not all, neurons, vulval muscles, vulval cells, the spermatheca, and secretory cells such as the uterine UV1 cells; UNC-31::GFP translational fusions localize to neuronal cell bodies, axonal projections and to sites of synaptic contact, consistent with other dense-core vesicle proteins.

  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Syntaxin-1A homolog

Locus: CELE_F56A8.7

Wormbase description: unc-64 encodes syntaxin, a plasma membrane receptor for intracellular vesicles that is orthologous to vertebrate syntaxin 1A (OMIM:186590) and Drosophila Syx1A; UNC-64 is required for normal locomotion and possibly also for insulin secretion; as an essential component of the core synaptic vesicle fusion machinery, UNC-64 interacts with UNC-13, a diacylglycerol-binding protein, and SNB-1/synaptobrevin; UNC-64 trafficking from the endoplasmic reticulum to the plasma membrane is mediated by UNC-18, an SM (Sec1, Munc18) family member; unc-64 mutations can be suppressed by mutations in slo-1, a calcium-activated potassium channel; UNC-64 is expressed ubiquitously in the nervous system and in secretory cells such as the vulval uv1 cell and the excretory gland cells.

Orthologs of unc-31;unc-64 in SynergyAge
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Species Gene
Orthologs of unc-31 in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of unc-64 in SynergyAge
Show in SynergyAge
Species Gene

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

Group webpage: www.aging-research.group