fem-1;fer-15;pat-4

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Genetic mutants with fem-1, fer-15, pat-4 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Lifespan (days)
25.1
Lifespan comparisons
Triple mutant fem-1(hc17);fer-15(b26);pat-4(RNAi) has a lifespan of 25.1 days, while double mutant fem-1(hc17);fer-15(b26) has a lifespan of 21.7 days.
Citation
View abstract
Hansen M et al., 2005, New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. PLoS Genet. 1(1):119-28 16103914 Click here to select all mutants from this PubMed ID in the graph
Abstract
Most of our knowledge about the regulation of aging comes from mutants originally isolated for other phenotypes. To ask whether our current view of aging has been affected by selection bias, and to deepen our understanding of known longevity pathways, we screened a genomic Caenorhabditis elegans RNAi library for clones that extend lifespan. We identified 23 new longevity genes affecting signal transduction, the stress response, gene expression, and metabolism and assigned these genes to specific longevity pathways. Our most important findings are (i) that dietary restriction extends C. elegans' lifespan by down-regulating expression of key genes, including a gene required for methylation of many macromolecules, (ii) that integrin signaling is likely to play a general, evolutionarily conserved role in lifespan regulation, and (iii) that specific lipophilic hormones may influence lifespan in a DAF-16/FOXO-dependent fashion. Surprisingly, of the new genes that have conserved sequence domains, only one could not be associated with a known longevity pathway. Thus, our current view of the genetics of aging has probably not been distorted substantially by selection bias.

Temperature °C
20
Lifespan (days)
26.0
Lifespan comparisons
Triple mutant fem-1(hc17);fer-15(b26);pat-4(RNAi) has a lifespan of 26.0 days, while double mutant fem-1(hc17);fer-15(b26) has a lifespan of 22.1 days.
Citation
View abstract
Hansen M et al., 2005, New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. PLoS Genet. 1(1):119-28 16103914 Click here to select all mutants from this PubMed ID in the graph
Abstract
Most of our knowledge about the regulation of aging comes from mutants originally isolated for other phenotypes. To ask whether our current view of aging has been affected by selection bias, and to deepen our understanding of known longevity pathways, we screened a genomic Caenorhabditis elegans RNAi library for clones that extend lifespan. We identified 23 new longevity genes affecting signal transduction, the stress response, gene expression, and metabolism and assigned these genes to specific longevity pathways. Our most important findings are (i) that dietary restriction extends C. elegans' lifespan by down-regulating expression of key genes, including a gene required for methylation of many macromolecules, (ii) that integrin signaling is likely to play a general, evolutionarily conserved role in lifespan regulation, and (iii) that specific lipophilic hormones may influence lifespan in a DAF-16/FOXO-dependent fashion. Surprisingly, of the new genes that have conserved sequence domains, only one could not be associated with a known longevity pathway. Thus, our current view of the genetics of aging has probably not been distorted substantially by selection bias.

Search genes: fem-1 fer-15 pat-4 fem-1;fer-15;pat-4

Entrez ID
Symbol
GenAge
Wormbase ID

177335
fem-1
View on GenAge (fem-1)
WBGene00001411

Sex-determining protein fem-1

Locus: CELE_F35D6.1

Wormbase description: The fem-1 gene encodes an ankyrin repeat-containing protein orthologous to human FEM1A and is required for masculinization of germline and somatic tissues; FEM-1 is widely expressed and functions as a second messenger in the sex determination pathway, connecting the membrane protein TRA-2A to the transcription factor TRA-1A which it negatively regulates; FEM-1 may also play a role in apoptosis, as it is a substrate for the CED-3 protease and can induce apoptosis when overexpressed in mammalian cells.

Symbol
GenAge

fer-15
View on GenAge (fer-15)

No gene information for fer-15

Entrez ID
Symbol
GenAge
Wormbase ID

175175
pat-4
View on GenAge (pat-4)
WBGene00003931

Integrin-linked protein kinase homolog pat-4

Locus: CELE_C29F9.7

Wormbase description: The pat-4 gene encodes a serine/threonine kinase orthologous to human integrin-linked kinase (ILK, OMIM:602366) and is required for formation of integrin-mediated muscle cell attachments during embryogenesis; PAT-4 probably functions as an adaptor molecule and localizes to dense bodies and M lines; PAT-4 forms a ternary complex with PAT-6/actopaxin and UNC-112, and requires UNC-112, UNC-52/perlecan, PAT-2/alpha integrin, and PAT-3/beta integrin for proper localization to newly forming integrin adhesion complexes.

Orthologs of fem-1;fer-15;pat-4 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene

Orthologs of fem-1 in SynergyAge

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Species	Gene

Orthologs of fer-15 in SynergyAge

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Species	Gene

Orthologs of pat-4 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	Ilk
Mus musculus	Ilk