atp-5;fem-1;fer-15

Lifespan changes: From wild type to atp-5;fem-1;fer-15

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Genetic mutants with atp-5, fem-1, fer-15 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    20

  • Lifespan (days)

    26.1

  • Lifespan comparisons

    Triple mutant atp-5(RNAi);fem-1(hc17);fer-15(b26) has a lifespan of 26.1 days, while double mutant fem-1(hc17);fer-15(b26) has a lifespan of 17.5 days.

  • Citation
    View abstract

    Hansen M et al., 2005, New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. PLoS Genet. 1(1):119-28 PubMed 16103914 Click here to select all mutants from this PubMed ID in the graph

Search genes: atp-5 fem-1 fer-15 atp-5;fem-1;fer-15
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

ATP synthase subunit


Locus: CELE_C06H2.1


Wormbase description: none available


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Sex-determining protein fem-1


Locus: CELE_F35D6.1


Wormbase description: The fem-1 gene encodes an ankyrin repeat-containing protein orthologous to human FEM1A and is required for masculinization of germline and somatic tissues; FEM-1 is widely expressed and functions as a second messenger in the sex determination pathway, connecting the membrane protein TRA-2A to the transcription factor TRA-1A which it negatively regulates; FEM-1 may also play a role in apoptosis, as it is a substrate for the CED-3 protease and can induce apoptosis when overexpressed in mammalian cells.


  • Symbol
  • GenAge

No gene information for fer-15


Orthologs of atp-5;fem-1;fer-15 in SynergyAge
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Orthologs of atp-5 in SynergyAge
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Species Gene
Orthologs of fem-1 in SynergyAge
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Species Gene
Orthologs of fer-15 in SynergyAge
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About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Contact
Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania
Email:

Group webpage: www.aging-research.group