Lifespan changes: From wild type to atg-9;mev-1

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Genetic mutants with atg-9, mev-1 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C


  • Lifespan (days)


  • Lifespan comparisons

    Double mutant atg-9(RNAi);mev-1(kn1) has a lifespan of 16.7 days, while single mutant mev-1(kn1) has a lifespan of 13.7 days.

  • Citation
    View abstract

    Hashimoto Y et al., 2009, Lifespan extension by suppression of autophagy genes in Caenorhabditis elegans. Genes Cells. 14(6):717-26 PubMed 19469880 Click here to select all mutants from this PubMed ID in the graph

Search genes: atg-9 mev-1
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

AuTophaGy (yeast Atg homolog);Autophagy-related protein 9

Locus: CELE_T22H9.2

Wormbase description: none available

  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Succinate dehydrogenase cytochrome b560 subunit, mitochondrial;hypothetical protein

Locus: CELE_T07C4.7

Wormbase description: mev-1 encodes the C. elegans ortholog of the succinate dehydrogenase cytochrome b560 subunit, an integral membrane protein that is a subunit of mitochondrial respiratory chain complex II (ubiquinol-cytochrome c reductase); MEV-1 is required for oxidative phosphorylation, and mev-1 mutations result abnormal energy metabolism and increased sensitivity to oxidative stress and pathogen infection; a mev-1 deletion mutation also has a shortened lifespan; MEV-1 localizes to mitochondria.

Orthologs of atg-9;mev-1 in SynergyAge
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Species Gene
Orthologs of atg-9 in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of mev-1 in SynergyAge
Show in SynergyAge
Species Gene

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020).

Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

Group webpage: