Lifespan changes: From wild type to atg-9;ced-3

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Genetic mutants with atg-9, ced-3 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C


  • Lifespan (days)


  • Lifespan comparisons

    Double mutant atg-9(RNAi);ced-3(n2433) has a lifespan of 25.7 days, while single mutant ced-3(n2433) has a lifespan of 19.3 days.

  • Citation
    View abstract

    Hashimoto Y et al., 2009, Lifespan extension by suppression of autophagy genes in Caenorhabditis elegans. Genes Cells. 14(6):717-26 PubMed 19469880 Click here to select all mutants from this PubMed ID in the graph

Search genes: atg-9 ced-3
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

AuTophaGy (yeast Atg homolog);Autophagy-related protein 9

Locus: CELE_T22H9.2

Wormbase description: none available

  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Cell death protein 3 subunit p17;hypothetical protein

Locus: CELE_C48D1.2

Wormbase description: ced-3 encodes a caspase, a cysteine-aspartate protease; CED-3 activity is required for execution of apoptosis and functions in a conserved genetic pathway with CED-4, CED-9, and EGL-1 to regulate apoptosis during C. elegans development.

Orthologs of atg-9;ced-3 in SynergyAge
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Species Gene
Orthologs of atg-9 in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of ced-3 in SynergyAge
Show in SynergyAge
Species Gene

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020).

Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

Group webpage: