eat-2;lin-15b;nhr-49;nre-1

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Genetic mutants with eat-2, lin-15b, nhr-49, nre-1 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Lifespan (days)
14.8
Lifespan comparisons
Quadruple mutant eat-2(ad465);lin-15b(hd126);nhr-49(RNAi);nre-1(hd20) has a lifespan of 14.8 days, while triple mutant lin-15b(hd126);nhr-49(RNAi);nre-1(hd20) has a lifespan of 10.98 days.
Citation
View abstract
Heestand BN et al., 2013;9(7):e1003651., Dietary restriction induced longevity is mediated by nuclear receptor NHR-62 in Caenorhabditis elegans. PLoS Genet. 9(7):e1003651 23935515 Click here to select all mutants from this PubMed ID in the graph
Abstract
Dietary restriction (DR) extends lifespan in a wide variety of species, yet the underlying mechanisms are not well understood. Here we show that the Caenorhabditis elegans HNF4α-related nuclear hormone receptor NHR-62 is required for metabolic and physiologic responses associated with DR-induced longevity. nhr-62 mediates the longevity of eat-2 mutants, a genetic mimetic of dietary restriction, and blunts the longevity response of DR induced by bacterial food dilution at low nutrient levels. Metabolic changes associated with DR, including decreased Oil Red O staining, decreased triglyceride levels, and increased autophagy are partly reversed by mutation of nhr-62. Additionally, the DR fatty acid profile is altered in nhr-62 mutants. Expression profiles reveal that several hundred genes induced by DR depend on the activity of NHR-62, including a putative lipase required for the DR response. This study provides critical evidence of nuclear hormone receptor regulation of the DR longevity response, suggesting hormonal and metabolic control of life span.

Search genes: eat-2 lin-15b nhr-49 nre-1 eat-2;lin-15b;nhr-49;nre-1

Entrez ID
Symbol
GenAge
Wormbase ID

175072
eat-2
View on GenAge (eat-2)
WBGene00001133

Neuronal acetylcholine receptor subunit eat-2

Locus: CELE_Y48B6A.4

Wormbase description: eat-2 encodes a ligand-gated ion channel subunit most closely related to the non-alpha-subunits of nicotinic acetylcholine receptors (nAChR); EAT-2 functions postsynaptically in pharyngeal muscle to regulate the rate of pharyngeal pumping; eat-2 is also required for normal life span and defecation; a functional EAT-2::GFP fusion protein localizes to two small dots near the junction of pharyngeal muscles pm4 and pm5, which is the site of the posterior-most MC motor neuron processes and the MC synapse; eat-2 genetically interacts with eat-18, which encodes a predicted novel transmembrane protein expressed in pharyngeal muscle and required for proper function of pharyngeal nicotonic receptors.

Symbol
GenAge

lin-15b
View on GenAge (lin-15b)

No gene information for lin-15b

Entrez ID
Symbol
GenAge
Wormbase ID

172839
nhr-49
View on GenAge (nhr-49)
WBGene00003639

Nuclear Hormone Receptor family;Nuclear hormone receptor family member nhr-49

Locus: CELE_K10C3.6

Wormbase description: nhr-49 encodes a nuclear hormone receptor (NHR) related to the mammalian HNF4 (hepatocyte nuclear factor 4) family of NHRs; nhr-49 functions as a key regulator of fat metabolism and lifespan by regulating induction of beta-oxidation genes upon food deprivation and activation of stearoyl-CoA desaturase in fed animals, respectively; NHR-49 activates transcription in conjunction with the MDT-15 mediator subunit with which it physically interacts.

Symbol
GenAge

nre-1
View on GenAge (nre-1)

No gene information for nre-1

Orthologs of eat-2;lin-15b;nhr-49;nre-1 in SynergyAge

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Orthologs of eat-2 in SynergyAge

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Orthologs of nhr-49 in SynergyAge

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Orthologs of nre-1 in SynergyAge

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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.