cco-1;nhr-62

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Genetic mutants with cco-1, nhr-62 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Lifespan (days)
30.53
Lifespan change (compared to wild type)
109.40%
Lifespan comparisons
Double mutant cco-1(RNAi);nhr-62(tm1818) has a lifespan of 30.53 days, while single mutant cco-1(RNAi) has a lifespan of 26.95 days, single mutant nhr-62(tm1818) has a lifespan of 17.49 days and wild type has a lifespan of 14.58 days.
Type of interaction
See methods
Synergistic (positive)
Citation
View abstract
Heestand BN et al., 2013;9(7):e1003651., Dietary restriction induced longevity is mediated by nuclear receptor NHR-62 in Caenorhabditis elegans. PLoS Genet. 9(7):e1003651 23935515 Click here to select all mutants from this PubMed ID in the graph
Abstract
Dietary restriction (DR) extends lifespan in a wide variety of species, yet the underlying mechanisms are not well understood. Here we show that the Caenorhabditis elegans HNF4α-related nuclear hormone receptor NHR-62 is required for metabolic and physiologic responses associated with DR-induced longevity. nhr-62 mediates the longevity of eat-2 mutants, a genetic mimetic of dietary restriction, and blunts the longevity response of DR induced by bacterial food dilution at low nutrient levels. Metabolic changes associated with DR, including decreased Oil Red O staining, decreased triglyceride levels, and increased autophagy are partly reversed by mutation of nhr-62. Additionally, the DR fatty acid profile is altered in nhr-62 mutants. Expression profiles reveal that several hundred genes induced by DR depend on the activity of NHR-62, including a putative lipase required for the DR response. This study provides critical evidence of nuclear hormone receptor regulation of the DR longevity response, suggesting hormonal and metabolic control of life span.

Temperature °C
20
Lifespan (days)
31.73
Lifespan change (compared to wild type)
92.42%
Lifespan comparisons
Double mutant cco-1(RNAi);nhr-62(tm1818) has a lifespan of 31.73 days, while single mutant cco-1(RNAi) has a lifespan of 29.09 days, single mutant nhr-62(tm1818) has a lifespan of 16.29 days and wild type has a lifespan of 16.49 days.
Type of interaction
See methods
Enhancer, opposite lifespan effects
Citation
View abstract
Heestand BN et al., 2013;9(7):e1003651., Dietary restriction induced longevity is mediated by nuclear receptor NHR-62 in Caenorhabditis elegans. PLoS Genet. 9(7):e1003651 23935515 Click here to select all mutants from this PubMed ID in the graph
Abstract
Dietary restriction (DR) extends lifespan in a wide variety of species, yet the underlying mechanisms are not well understood. Here we show that the Caenorhabditis elegans HNF4α-related nuclear hormone receptor NHR-62 is required for metabolic and physiologic responses associated with DR-induced longevity. nhr-62 mediates the longevity of eat-2 mutants, a genetic mimetic of dietary restriction, and blunts the longevity response of DR induced by bacterial food dilution at low nutrient levels. Metabolic changes associated with DR, including decreased Oil Red O staining, decreased triglyceride levels, and increased autophagy are partly reversed by mutation of nhr-62. Additionally, the DR fatty acid profile is altered in nhr-62 mutants. Expression profiles reveal that several hundred genes induced by DR depend on the activity of NHR-62, including a putative lipase required for the DR response. This study provides critical evidence of nuclear hormone receptor regulation of the DR longevity response, suggesting hormonal and metabolic control of life span.

Search genes: cco-1 nhr-62

Symbol
GenAge

cco-1
View on GenAge (cco-1)

No gene information for cco-1

Entrez ID
Symbol
GenAge
Wormbase ID

172836
nhr-62
View on GenAge (nhr-62)
WBGene00003652

Nuclear hormone receptor family member nhr-62

Locus: CELE_Y67A6A.2

Wormbase description: none available

Orthologs of cco-1;nhr-62 in SynergyAge

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Orthologs of cco-1 in SynergyAge

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Orthologs of nhr-62 in SynergyAge

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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.