let-363;nhr-62

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Genetic mutants with let-363, nhr-62 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Lifespan (days)
20.76
Lifespan change (compared to wild type)
39.14%
Lifespan comparisons
Double mutant let-363(RNAi);nhr-62(tm1818) has a lifespan of 20.76 days, while single mutant let-363(RNAi) has a lifespan of 19.14 days, single mutant nhr-62(tm1818) has a lifespan of 17.25 days and wild type has a lifespan of 14.92 days.
Type of interaction
See methods
Almost additive (positive)
Citation
View abstract
Heestand BN et al., 2013;9(7):e1003651., Dietary restriction induced longevity is mediated by nuclear receptor NHR-62 in Caenorhabditis elegans. PLoS Genet. 9(7):e1003651 23935515 Click here to select all mutants from this PubMed ID in the graph
Abstract
Dietary restriction (DR) extends lifespan in a wide variety of species, yet the underlying mechanisms are not well understood. Here we show that the Caenorhabditis elegans HNF4α-related nuclear hormone receptor NHR-62 is required for metabolic and physiologic responses associated with DR-induced longevity. nhr-62 mediates the longevity of eat-2 mutants, a genetic mimetic of dietary restriction, and blunts the longevity response of DR induced by bacterial food dilution at low nutrient levels. Metabolic changes associated with DR, including decreased Oil Red O staining, decreased triglyceride levels, and increased autophagy are partly reversed by mutation of nhr-62. Additionally, the DR fatty acid profile is altered in nhr-62 mutants. Expression profiles reveal that several hundred genes induced by DR depend on the activity of NHR-62, including a putative lipase required for the DR response. This study provides critical evidence of nuclear hormone receptor regulation of the DR longevity response, suggesting hormonal and metabolic control of life span.

Temperature °C
20
Lifespan (days)
20.78
Lifespan change (compared to wild type)
30.53%
Lifespan comparisons
Double mutant let-363(RNAi);nhr-62(tm1818) has a lifespan of 20.78 days, while single mutant let-363(RNAi) has a lifespan of 17.97 days, single mutant nhr-62(tm1818) has a lifespan of 17.54 days and wild type has a lifespan of 15.92 days.
Type of interaction
See methods
Synergistic (positive)
Citation
View abstract
Heestand BN et al., 2013;9(7):e1003651., Dietary restriction induced longevity is mediated by nuclear receptor NHR-62 in Caenorhabditis elegans. PLoS Genet. 9(7):e1003651 23935515 Click here to select all mutants from this PubMed ID in the graph
Abstract
Dietary restriction (DR) extends lifespan in a wide variety of species, yet the underlying mechanisms are not well understood. Here we show that the Caenorhabditis elegans HNF4α-related nuclear hormone receptor NHR-62 is required for metabolic and physiologic responses associated with DR-induced longevity. nhr-62 mediates the longevity of eat-2 mutants, a genetic mimetic of dietary restriction, and blunts the longevity response of DR induced by bacterial food dilution at low nutrient levels. Metabolic changes associated with DR, including decreased Oil Red O staining, decreased triglyceride levels, and increased autophagy are partly reversed by mutation of nhr-62. Additionally, the DR fatty acid profile is altered in nhr-62 mutants. Expression profiles reveal that several hundred genes induced by DR depend on the activity of NHR-62, including a putative lipase required for the DR response. This study provides critical evidence of nuclear hormone receptor regulation of the DR longevity response, suggesting hormonal and metabolic control of life span.

Search genes: let-363 nhr-62

Entrez ID
Symbol
GenAge
Wormbase ID

172167
let-363
View on GenAge (let-363)
WBGene00002583

Target of rapamycin homolog

Locus: CELE_B0261.2

Wormbase description: none available

Entrez ID
Symbol
GenAge
Wormbase ID

172836
nhr-62
View on GenAge (nhr-62)
WBGene00003652

Nuclear hormone receptor family member nhr-62

Locus: CELE_Y67A6A.2

Wormbase description: none available

Orthologs of let-363;nhr-62 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene

Orthologs of let-363 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	Tor
Mus musculus	Mtor

Orthologs of nhr-62 in SynergyAge

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Species	Gene