lin-15b;nhr-35;nre-1

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Genetic mutants with lin-15b, nhr-35, nre-1 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Lifespan (days)
11.35
Lifespan comparisons
Triple mutant lin-15b(hd126);nhr-35(RNAi);nre-1(hd20) has a lifespan of 11.35 days, while double mutant lin-15b(hd126);nre-1(hd20) has a lifespan of 11.54 days.
Citation
View abstract
Heestand BN et al., 2013;9(7):e1003651., Dietary restriction induced longevity is mediated by nuclear receptor NHR-62 in Caenorhabditis elegans. PLoS Genet. 9(7):e1003651 23935515 Click here to select all mutants from this PubMed ID in the graph
Abstract
Dietary restriction (DR) extends lifespan in a wide variety of species, yet the underlying mechanisms are not well understood. Here we show that the Caenorhabditis elegans HNF4α-related nuclear hormone receptor NHR-62 is required for metabolic and physiologic responses associated with DR-induced longevity. nhr-62 mediates the longevity of eat-2 mutants, a genetic mimetic of dietary restriction, and blunts the longevity response of DR induced by bacterial food dilution at low nutrient levels. Metabolic changes associated with DR, including decreased Oil Red O staining, decreased triglyceride levels, and increased autophagy are partly reversed by mutation of nhr-62. Additionally, the DR fatty acid profile is altered in nhr-62 mutants. Expression profiles reveal that several hundred genes induced by DR depend on the activity of NHR-62, including a putative lipase required for the DR response. This study provides critical evidence of nuclear hormone receptor regulation of the DR longevity response, suggesting hormonal and metabolic control of life span.

Temperature °C
20
Lifespan (days)
13.11
Citation
View abstract
Heestand BN et al., 2013;9(7):e1003651., Dietary restriction induced longevity is mediated by nuclear receptor NHR-62 in Caenorhabditis elegans. PLoS Genet. 9(7):e1003651 23935515 Click here to select all mutants from this PubMed ID in the graph
Abstract
Dietary restriction (DR) extends lifespan in a wide variety of species, yet the underlying mechanisms are not well understood. Here we show that the Caenorhabditis elegans HNF4α-related nuclear hormone receptor NHR-62 is required for metabolic and physiologic responses associated with DR-induced longevity. nhr-62 mediates the longevity of eat-2 mutants, a genetic mimetic of dietary restriction, and blunts the longevity response of DR induced by bacterial food dilution at low nutrient levels. Metabolic changes associated with DR, including decreased Oil Red O staining, decreased triglyceride levels, and increased autophagy are partly reversed by mutation of nhr-62. Additionally, the DR fatty acid profile is altered in nhr-62 mutants. Expression profiles reveal that several hundred genes induced by DR depend on the activity of NHR-62, including a putative lipase required for the DR response. This study provides critical evidence of nuclear hormone receptor regulation of the DR longevity response, suggesting hormonal and metabolic control of life span.

Search genes: lin-15b nhr-35 nre-1 lin-15b;nhr-35;nre-1

Symbol
GenAge

lin-15b
View on GenAge (lin-15b)

No gene information for lin-15b

Entrez ID
Symbol
GenAge
Wormbase ID

180725
nhr-35
View on GenAge (nhr-35)
WBGene00003628

Nuclear hormone receptor family member nhr-35

Locus: CELE_C07A12.3

Wormbase description: none available

Symbol
GenAge

nre-1
View on GenAge (nre-1)

No gene information for nre-1

Orthologs of lin-15b;nhr-35;nre-1 in SynergyAge

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Orthologs of lin-15b in SynergyAge

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Orthologs of nhr-35 in SynergyAge

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Orthologs of nre-1 in SynergyAge

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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.