Lifespan changes: From wild type to HDAC1;Sirt1 DF = decrease in function; IF = increase in function
rpd3[def24];dSir[17]
25
high-calorie (15% yeast, 15% sucrose, and 2% agar)
66.0
Flies with both a dSir2 mutation and rpd3 (def24) mutation were not long-lived, whereas their counterparts, flies mutant for only rpd3(def24), remained long-livedr2 and Rpd3, therefore, seem to be in the calorie-reduction life-span-extending pathway in flies.
Double mutant dSir2(IF);rpd3(IF) has a lifespan of 66.0 days, while single mutant dSir2(IF) has a lifespan of 68.0 days and single mutant rpd3(IF) has a lifespan of 85.0 days.
Rogina B, Helfand SL, 2004, Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc Natl Acad Sci U S A. 101(45):15998-6003 15520384 Click here to select all mutants from this PubMed ID in the graph
rpd3[def24];dSir2[EP2300]
25
high-calorie (15% yeast, 15% sucrose, and 2% agar)
48.0
-5.88%
Double mutant dSir2(IF);rpd3(IF) has a lifespan of 48.0 days, while single mutant rpd3(IF) has a lifespan of 59.0 days and wild type has a lifespan of 51.0 days.
Contains dependence
Rogina B, Helfand SL, 2004, Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc Natl Acad Sci U S A. 101(45):15998-6003 15520384 Click here to select all mutants from this PubMed ID in the graph
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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group