alpha-Man-Ia;Edem1

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Genetic mutants with alpha-Man-Ia, Edem1 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Strain
P{EP}p1130[EP1130];P{EP}Edem1[EP1588]
Temperature °C
25
Diet
standard food
Lifespan (days)
58.0
Lifespan change (compared to wild type)
31.82%
Phenotype
The transheterozygotes for mas1 and Edem1 showed similar lifespan profiles to those resulting from crossing for different alleles of mas1. These results support the hypothesis that the two genes act to extend longevity through a common genetic pathway.
Lifespan comparisons
Double mutant edem1(DF);mas-1(DF) has a lifespan of 58.0 days, while single mutant edem1(DF) has a lifespan of 52.0 days, single mutant mas-1(DF) has a lifespan of 65.0 days and wild type has a lifespan of 44.0 days.
Type of interaction
See methods
Dependent
Citation
View abstract
Liu YL et al., 2009, Reduced expression of alpha-1,2-mannosidase I extends lifespan in Drosophila melanogaster and Caenorhabditis elegans. Aging Cell. 8(4):370-9 19302370 Click here to select all mutants from this PubMed ID in the graph
Abstract
Exposure to sub-lethal levels of stress, or hormesis, was a means to induce longevity. By screening for mutations that enhance resistance to multiple stresses, we identified multiple alleles of alpha-1,2-mannosidase I (mas1) which, in addition to promoting stress resistance, also extended longevity. Longevity enhancement is also observed when mas1 expression is reduced via RNA interference in both Drosophila melanogaster and Caenorhabditis elegans. The screen also identified Edem1 (Edm1), a gene downstream of mas1, as a modulator of lifespan. As double mutants for both mas1 and Edm1 showed no additional longevity enhancement, it appeared that both mutations function within a common pathway to extend lifespan. Molecular analysis of these mutants revealed that the expression of BiP, a putative biomarker of dietary restriction (DR), is down-regulated in response to reductions in mas1 expression. These findings suggested that mutations in mas1 may extend longevity by modulating DR.

Strain
alpha-Man-la[EP1628];P{EP}Edem1[EP1588]
Temperature °C
25
Diet
standard food
Lifespan (days)
62.0
Lifespan change (compared to wild type)
40.91%
Phenotype
The transheterozygotes for mas1 and Edem1 showed similar lifespan profiles to those resulting from crossing for different alleles of mas1. These results support the hypothesis that the two genes act to extend longevity through a common genetic pathway.
Lifespan comparisons
Double mutant edem1(DF);mas-1(DF) has a lifespan of 62.0 days, while single mutant edem1(DF) has a lifespan of 52.0 days, single mutant mas-1(DF) has a lifespan of 57.0 days and wild type has a lifespan of 44.0 days.
Type of interaction
See methods
Almost additive (positive)
Citation
View abstract
Liu YL et al., 2009, Reduced expression of alpha-1,2-mannosidase I extends lifespan in Drosophila melanogaster and Caenorhabditis elegans. Aging Cell. 8(4):370-9 19302370 Click here to select all mutants from this PubMed ID in the graph
Abstract
Exposure to sub-lethal levels of stress, or hormesis, was a means to induce longevity. By screening for mutations that enhance resistance to multiple stresses, we identified multiple alleles of alpha-1,2-mannosidase I (mas1) which, in addition to promoting stress resistance, also extended longevity. Longevity enhancement is also observed when mas1 expression is reduced via RNA interference in both Drosophila melanogaster and Caenorhabditis elegans. The screen also identified Edem1 (Edm1), a gene downstream of mas1, as a modulator of lifespan. As double mutants for both mas1 and Edm1 showed no additional longevity enhancement, it appeared that both mutations function within a common pathway to extend lifespan. Molecular analysis of these mutants revealed that the expression of BiP, a putative biomarker of dietary restriction (DR), is down-regulated in response to reductions in mas1 expression. These findings suggested that mutations in mas1 may extend longevity by modulating DR.

Strain
alpha-Man-la[EP982];P{EP}Edem1[EP1588]
Temperature °C
25
Diet
standard food
Lifespan (days)
60.0
Lifespan change (compared to wild type)
36.36%
Phenotype
The transheterozygotes for mas1 and Edem1 showed similar lifespan profiles to those resulting from crossing for different alleles of mas1. These results support the hypothesis that the two genes act to extend longevity through a common genetic pathway.
Lifespan comparisons
Double mutant edem1(DF);mas-1(DF) has a lifespan of 60.0 days, while single mutant edem1(DF) has a lifespan of 52.0 days, single mutant mas-1(DF) has a lifespan of 57.0 days and wild type has a lifespan of 44.0 days.
Type of interaction
See methods
Almost additive (positive)
Citation
View abstract
Liu YL et al., 2009, Reduced expression of alpha-1,2-mannosidase I extends lifespan in Drosophila melanogaster and Caenorhabditis elegans. Aging Cell. 8(4):370-9 19302370 Click here to select all mutants from this PubMed ID in the graph
Abstract
Exposure to sub-lethal levels of stress, or hormesis, was a means to induce longevity. By screening for mutations that enhance resistance to multiple stresses, we identified multiple alleles of alpha-1,2-mannosidase I (mas1) which, in addition to promoting stress resistance, also extended longevity. Longevity enhancement is also observed when mas1 expression is reduced via RNA interference in both Drosophila melanogaster and Caenorhabditis elegans. The screen also identified Edem1 (Edm1), a gene downstream of mas1, as a modulator of lifespan. As double mutants for both mas1 and Edm1 showed no additional longevity enhancement, it appeared that both mutations function within a common pathway to extend lifespan. Molecular analysis of these mutants revealed that the expression of BiP, a putative biomarker of dietary restriction (DR), is down-regulated in response to reductions in mas1 expression. These findings suggested that mutations in mas1 may extend longevity by modulating DR.

Search genes: alpha-Man-Ia Edem1

Entrez ID
Symbol
GenAge
FlyBase ID

31957
alpha-Man-Ia
View on GenAge (alpha-Man-Ia)
FBgn0259170

alpha-Mannosidase class I a

Locus: Dmel_CG42275

Entrez ID
Symbol
GenAge
FlyBase ID

31154
Edem1
View on GenAge (Edem1)
FBgn0023511

ER degradation enhancer, mannosidase alpha-like 1

Locus: Dmel_CG3810

Orthologs of alpha-Man-Ia;Edem1 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Mus musculus	Edem2;Man1a2
Mus musculus	Edem2;Man1a
Mus musculus	Man1a2;Edem2
Mus musculus	Man1a;Edem2

Orthologs of alpha-Man-Ia in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Caenorhabditis elegans	mans-1
Mus musculus	Man1a2
Mus musculus	Man1a

Orthologs of Edem1 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Mus musculus	Edem2