Lifespan changes: From wild type to ATPCL;chm DF = decrease in function; IF = increase in function

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Genetic mutants with ATPCL, chm alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Strain


  • Temperature °C


  • Diet

    water, 1.2% agar, 1.8% yeast, 1% soja, 2.2% sugar syrup, 8% corn extract, 8% malt extract, 0.24% Nipagin, and 6.25 ul/l of propionic acid and yeast extra powder

  • Lifespan (days)


  • Lifespan comparisons

    Double mutant ATPCL(DF);chm(DF) has a lifespan of 54.0 days, while single mutant ATPCL(DF) has a lifespan of 57.0 days.

  • Citation
    View abstract

    Peleg S et al., 2016, Life span extension by targeting a link between metabolism and histone acetylation in Drosophila. EMBO Rep. 17(3):455-69 PubMed 26781291 Click here to select all mutants from this PubMed ID in the graph

Search genes: ATPCL chm
  • Entrez ID
  • Symbol
  • GenAge
  • FlyBase ID

ATP citrate lyase

Locus: Dmel_CG8322

  • Entrez ID
  • Symbol
  • GenAge
  • FlyBase ID


Locus: Dmel_CG5229

Orthologs of ATPCL;chm in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of ATPCL in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of chm in SynergyAge
Show in SynergyAge
Species Gene

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020).

Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

Group webpage: