Lifespan changes: From wild type to Trx-2;TrxT DF = decrease in function; IF = increase in function

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Genetic mutants with Trx-2, TrxT alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Strain


  • Temperature °C


  • Lifespan (days)


  • Lifespan change (compared to wild type)


  • Phenotype

    The TrxT- mutant (w Df(1)J5) had very similar lifespans to the control and the double mutant had only a slightly shorter lifespan than the single TrxT mutant.

  • Lifespan comparisons

    Double mutant Trx-2(DF);TrxT(DF) has a lifespan of 46.9 days, while single mutant TrxT(DF) has a lifespan of 50.4 days, single mutant Trx-2(DF) has a lifespan of 38.4 days and wild type has a lifespan of 50.8 days.

  • Type of interaction
    See methods


  • Citation
    View abstract

    Svensson MJ, Larsson J, 2007, Thioredoxin-2 affects lifespan and oxidative stress in Drosophila. Hereditas. 144(1):25-32 PubMed 17567437 Click here to select all mutants from this PubMed ID in the graph

Search genes: Trx-2 TrxT
  • Entrez ID
  • Symbol
  • GenAge
  • FlyBase ID


Locus: Dmel_CG31884

  • Entrez ID
  • Symbol
  • GenAge
  • FlyBase ID

Thioredoxin T

Locus: Dmel_CG3315

Orthologs of Trx-2;TrxT in SynergyAge
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Species Gene
Orthologs of Trx-2 in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of TrxT in SynergyAge
Show in SynergyAge
Species Gene

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020).

Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

Group webpage: