Lifespan changes: From wild type to dhd;Trx-2 DF = decrease in function; IF = increase in function

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Genetic mutants with dhd, Trx-2 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Strain


  • Temperature °C


  • Lifespan (days)


  • Lifespan change (compared to wild type)


  • Phenotype

    The dhd- mutant (w Df(1)J5) had very similar lifespans to the control and the double mutant had only a slightly shorter lifespan than the single dhd- mutant.

  • Lifespan comparisons

    Double mutant Trx-2(DF);dhd(DF) has a lifespan of 51.5 days, while single mutant dhd(DF) has a lifespan of 53.0 days, single mutant Trx-2(DF) has a lifespan of 53.5 days and wild type has a lifespan of 53.7 days.

  • Type of interaction
    See methods

    Synergistic (negative)

  • Citation
    View abstract

    Svensson MJ, Larsson J, 2007, Thioredoxin-2 affects lifespan and oxidative stress in Drosophila. Hereditas. 144(1):25-32 PubMed 17567437 Click here to select all mutants from this PubMed ID in the graph

Search genes: dhd Trx-2
  • Entrez ID
  • Symbol
  • GenAge
  • FlyBase ID


Locus: Dmel_CG4193

  • Entrez ID
  • Symbol
  • GenAge
  • FlyBase ID


Locus: Dmel_CG31884

Orthologs of dhd;Trx-2 in SynergyAge
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Species Gene
Orthologs of dhd in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of Trx-2 in SynergyAge
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Species Gene

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

Group webpage: www.aging-research.group