Lifespan changes: From wild type to foxo;rpr DF = decrease in function; IF = increase in function

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Genetic mutants with foxo, rpr alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Strain


  • Temperature °C


  • Diet

    sugar/yeast medium

  • Lifespan (days)


  • Lifespan change (compared to wild type)


  • Phenotype

    Expression of UAS-reaper (UAS-rpr) under the control of the InsP3-GAL4 driver (InsP3GAL), which results in the ablation of median neurosecretary cells, results in females having a significantly longer median lifespan than controls. The same effect is however completely cancelled out in a dFoxo background, suggesting that the increase in lifespan by rpr expression is dependent on the existence of dFoxo. It should be noted that homozygotes dfoxo mutant (delta 94) female flies, which have delayed development time, are smaller in size with significant reductions in both body weight and wing area, are short leaved by ~33%.

  • Lifespan comparisons

    Double mutant foxo(DF);rpr(UAS-rpr) has a lifespan of 44.0 days, while single mutant rpr(UAS-rpr) has a lifespan of 82.0 days, single mutant foxo(DF) has a lifespan of 41.0 days and wild type has a lifespan of 60.0 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Slack C et al., 2011, dFOXO-independent effects of reduced insulin-like signaling in Drosophila. Aging Cell. 10(5):735-48 PubMed 21443682 Click here to select all mutants from this PubMed ID in the graph

Search genes: foxo rpr
  • Entrez ID
  • Symbol
  • GenAge
  • FlyBase ID

forkhead box, sub-group O

Locus: Dmel_CG3143

  • Entrez ID
  • Symbol
  • GenAge
  • FlyBase ID


Locus: Dmel_CG4319

Orthologs of foxo;rpr in SynergyAge
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Species Gene
Orthologs of foxo in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of rpr in SynergyAge
Show in SynergyAge
Species Gene

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020).

Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

Group webpage: