InR

Lifespan changes: From wild type to InR / From InR to multiple mutants DF = decrease in function; IF = increase in function

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Genetic mutants with InR alterations

  • Strain

    P{UAS-InR.DN.U}

  • Temperature °C

    25

  • Diet

    sugar/yeast medium

  • Lifespan (days)

    71.0

  • Lifespan change (compared to wild type)

    16.39%

  • Lifespan comparisons

    Single mutant inR(DF) has a lifespan of 71.0 days, while wild type has a lifespan of 61.0 days.

  • Citation
    View abstract

    Slack C et al., 2011, dFOXO-independent effects of reduced insulin-like signaling in Drosophila. Aging Cell. 10(5):735-48 PubMed 21443682 Click here to select all mutants from this PubMed ID in the graph

  • Strain

    P{UAS-InR.DN.U}

  • Temperature °C

    25

  • Diet

    sugar/yeast medium

  • Lifespan (days)

    83.0

  • Lifespan change (compared to wild type)

    23.88%

  • Lifespan comparisons

    Single mutant inR(DF) has a lifespan of 83.0 days, while wild type has a lifespan of 67.0 days.

  • Citation
    View abstract

    Slack C et al., 2011, dFOXO-independent effects of reduced insulin-like signaling in Drosophila. Aging Cell. 10(5):735-48 PubMed 21443682 Click here to select all mutants from this PubMed ID in the graph

Search genes: InR
  • Entrez ID
  • Symbol
  • GenAge
  • FlyBase ID

Insulin-like receptor


Locus: Dmel_CG18402


Orthologs of InR in SynergyAge
Show in SynergyAge
Species Gene
Caenorhabditis elegans daf-2
About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Contact
Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania
Email:

Group webpage: www.aging-research.group