Lifespan changes: From wild type to Pi3K92E / From Pi3K92E to multiple mutants DF = decrease in function; IF = increase in function
Single mutant Pi3K92E(DF) has a lifespan of 80.0 days, while wild type has a lifespan of 75.0 days.
Slack C et al., 2011, dFOXO-independent effects of reduced insulin-like signaling in Drosophila. Aging Cell. 10(5):735-48 21443682 Click here to select all mutants from this PubMed ID in the graph
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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group