Lifespan changes: From wild type to foxo;Pi3K92E DF = decrease in function; IF = increase in function

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Genetic mutants with foxo, Pi3K92E alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Strain


  • Temperature °C


  • Diet

    sugar/yeast medium

  • Lifespan (days)


  • Lifespan change (compared to wild type)


  • Phenotype

    Adult-conditioned expression of a catalytically inactive, dominant negative form of PI3 kinase (UAS-Dp110DN) under the control of the inducible daughterless-GeneSwitch (daGS) driver, results in females having a significantly longer median lifespan than controls. The same effect is however completely cancelled out in a dFoxo background, suggesting that the increase in lifespan by InR knock-down is dependent on the existence of dFoxo. It should be noted that homozygotes dfoxo mutant (delta 94) female flies, which have delayed development time, are smaller in size with significant reductions in both body weight and wing area, are short leaved by ~33%.

  • Lifespan comparisons

    Double mutant Pi3K92E(DF);foxo(DF) has a lifespan of 51.0 days, while single mutant Pi3K92E(DF) has a lifespan of 80.0 days, single mutant foxo(DF) has a lifespan of 54.0 days and wild type has a lifespan of 75.0 days.

  • Type of interaction
    See methods

    Enhancer, opposite lifespan effects

  • Citation
    View abstract

    Slack C et al., 2011, dFOXO-independent effects of reduced insulin-like signaling in Drosophila. Aging Cell. 10(5):735-48 PubMed 21443682 Click here to select all mutants from this PubMed ID in the graph

Search genes: foxo Pi3K92E
  • Entrez ID
  • Symbol
  • GenAge
  • FlyBase ID

forkhead box, sub-group O

Locus: Dmel_CG3143

  • Entrez ID
  • Symbol
  • GenAge
  • FlyBase ID


Locus: Dmel_CG4141

Orthologs of foxo;Pi3K92E in SynergyAge
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Species Gene
Orthologs of foxo in SynergyAge
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Species Gene
Orthologs of Pi3K92E in SynergyAge
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Species Gene
Caenorhabditis elegans age-1

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020).

Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

Group webpage: