daf-16;osm-3

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Genetic mutants with daf-16, osm-3 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Lifespan (days)
19.2
Lifespan change (compared to wild type)
2.13%
Phenotype
Loss of daf-16 markedly reduced but, in most cases, did not completely eliminate lifespan extension. Thus, most of this lifespan extension requires daf-16 activity, but a fraction is daf-16 independent. daf-16 could act downstream of a sensory signal to regulate lifespan, or it could act in a parallel pathway to provide an activity that these animals simply require for their longevity.
Lifespan comparisons
Double mutant daf-16(mu86);osm-3(p802) has a lifespan of 19.2 days, while single mutant osm-3(p802) has a lifespan of 30.6 days and wild type has a lifespan of 18.8 days.
Type of interaction
See methods
Contains dependence
Citation
View abstract
Apfeld J, Kenyon C, 1999, Regulation of lifespan by sensory perception in Caenorhabditis elegans. Nature. 402(6763):804-9 10617200 Click here to select all mutants from this PubMed ID in the graph
Abstract
Caenorhabditis elegans senses environmental signals through ciliated sensory neurons located primarily in sensory organs in the head and tail. Cilia function as sensory receptors, and mutants with defective sensory cilia have impaired sensory perception. Cilia are membrane-bound microtubule-based structures and in C. elegans are only found at the dendritic endings of sensory neurons. Here we show that mutations that cause defects in sensory cilia or their support cells, or in sensory signal transduction, extend lifespan. Our findings imply that sensory perception regulates the lifespan of this animal, and suggest that in nature, its lifespan may be regulated by environmental cues.

Search genes: daf-16 osm-3

Entrez ID
Symbol
GenAge
Wormbase ID

172981
daf-16
View on GenAge (daf-16)
WBGene00000912

Forkhead box protein O;hypothetical protein

Locus: CELE_R13H8.1

Wormbase description: daf-16 encodes the sole C. elegans forkhead box O (FOXO) homologue; DAF-16 functions as a transcription factor that acts in the insulin/IGF-1-mediated signaling (IIS) pathway that regulates dauer formation, longevity, fat metabolism, stress response, and innate immunity; DAF-16 regulates these various processes through isoform-specific expression, isoform-specific regulation by different AKT kinases, and differential regulation of target genes; DAF-16 can interact with the CBP-1 transcription cofactor in vitro, and interacts genetically with other genes in the insulin signaling and with daf-12, which encodes a nuclear hormone receptor; DAF-16 is activated in response to DNA damage during development and co-regulated by EGL-27, alleviates DNA-damage-induced developmental arrest by inducing DAF-16-associated element (DAE)-regulated genes; DAF-16 is broadly expressed but displays isoform-specific tissue enrichment; DAF-16 localizes to both the cytoplasm and the nucleus, with the ratio between the two an important regulator of function.

Entrez ID
Symbol
GenAge
Wormbase ID

177141
osm-3
View on GenAge (osm-3)
WBGene00003884

Osmotic avoidance abnormal protein 3

Locus: CELE_M02B7.3

Wormbase description: osm-3 encodes a kinesin-2 family member that forms a homodimeric kinesin motor protein; OSM-3, in conjunction with the heterotrimeric kinesin-II composed of KLP-20, KLP-11, and KAP-1, is required for intraflagellar transport (IFT) along the middle segment of the cilia and on its own, is required for IFT along the distal segment; OSM-3 is thus also required for formation of the distal segment of amphid channel cilia, responses to osmotic stimuli, dauer formation, and sensitivity to caffeine; OSM-3 is intensely localized in the ciliated endings of amphid, inner labial, and phasmid chemosensory neurons and shows a punctate localization pattern in the corresponding cell bodies and dendrites.

Orthologs of daf-16;osm-3 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene

Orthologs of daf-16 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Mus musculus	Foxo6
Mus musculus	Foxo1
Mus musculus	Foxo4
Mus musculus	Foxo3

Orthologs of osm-3 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	Kif3C

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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.