Lifespan changes: From wild type to hep;puc DF = decrease in function; IF = increase in function

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Genetic mutants with hep, puc alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Strain


  • Temperature °C


  • Diet

    cornmeal and molasses standard food

  • Lifespan (days)


  • Phenotype

    The extension of lifespan by puc heterozygosity requires functional Hep. hep 1 hemizygous males exhibit lifespan comparable to wild-type flies. Reduction of the puc gene-dose only marginally extends lifespan in these flies. Compared to puc mutants in a wild-type background, hep 1 reduces lifespan.

  • Lifespan comparisons

    Double mutant hep(DF);puc(DF) has a lifespan of 46.0 days, while single mutant puc(DF) has a lifespan of 57.0 days and single mutant hep(DF) has a lifespan of 41.0 days.

  • Citation
    View abstract

    Wang MC et al., 2003, JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila. Dev Cell. 5(5):811-6 PubMed 14602080 Click here to select all mutants from this PubMed ID in the graph

Search genes: hep puc
  • Entrez ID
  • Symbol
  • GenAge
  • FlyBase ID


Locus: Dmel_CG4353

  • Entrez ID
  • Symbol
  • GenAge
  • FlyBase ID


Locus: Dmel_CG7850

Orthologs of hep;puc in SynergyAge
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Species Gene
Orthologs of hep in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of puc in SynergyAge
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Species Gene

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

Group webpage: www.aging-research.group