Lip2;rpr

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Genetic mutants with Lip2, rpr alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Strain
rpr[UAS.C];dil[2]
Lifespan (days)
64.0
Lifespan change (compared to wild type)
36.17%
Phenotype
mNSC-ablated flies are long-lived and females show reduced fecundity.
Lifespan comparisons
Double mutant Lip2(DF);rpr(DF) has a lifespan of 64.0 days, while single mutant rpr(DF) has a lifespan of 54.0 days, single mutant Lip2(DF) has a lifespan of 47.0 days and wild type has a lifespan of 47.0 days.
Type of interaction
See methods
Synergistic (positive)
Citation
View abstract
Broughton SJ et al., 2005, Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands. Proc Natl Acad Sci U S A. 102(8):3105-10 15708981 Click here to select all mutants from this PubMed ID in the graph
Abstract
The insulin/insulin-like growth factor-like signaling pathway, present in all multicellular organisms, regulates diverse functions including growth, development, fecundity, metabolic homeostasis, and lifespan. In flies, ligands of the insulin/insulin-like growth factor-like signaling pathway, the Drosophila insulin-like peptides, regulate growth and hemolymph carbohydrate homeostasis during development and are expressed in a stage- and tissue-specific manner. Here, we show that ablation of Drosophila insulin-like peptide-producing median neurosecretory cells in the brain leads to increased fasting glucose levels in the hemolymph of adults similar to that found in diabetic mammals. They also exhibit increased storage of lipid and carbohydrate, reduced fecundity, and reduced tolerance of heat and cold. However, the ablated flies show an extension of median and maximal lifespan and increased resistance to oxidative stress and starvation.

Strain
rpr[UAS.C];dil[2]
Lifespan (days)
56.0
Lifespan change (compared to wild type)
60.00%
Phenotype
mNSC-ablated flies are long-lived and females show reduced fecundity.
Lifespan comparisons
Double mutant Lip2(DF);rpr(DF) has a lifespan of 56.0 days, while single mutant rpr(DF) has a lifespan of 42.0 days, single mutant Lip2(DF) has a lifespan of 32.0 days and wild type has a lifespan of 35.0 days.
Type of interaction
See methods
Enhancer, opposite lifespan effects
Citation
View abstract
Broughton SJ et al., 2005, Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands. Proc Natl Acad Sci U S A. 102(8):3105-10 15708981 Click here to select all mutants from this PubMed ID in the graph
Abstract
The insulin/insulin-like growth factor-like signaling pathway, present in all multicellular organisms, regulates diverse functions including growth, development, fecundity, metabolic homeostasis, and lifespan. In flies, ligands of the insulin/insulin-like growth factor-like signaling pathway, the Drosophila insulin-like peptides, regulate growth and hemolymph carbohydrate homeostasis during development and are expressed in a stage- and tissue-specific manner. Here, we show that ablation of Drosophila insulin-like peptide-producing median neurosecretory cells in the brain leads to increased fasting glucose levels in the hemolymph of adults similar to that found in diabetic mammals. They also exhibit increased storage of lipid and carbohydrate, reduced fecundity, and reduced tolerance of heat and cold. However, the ablated flies show an extension of median and maximal lifespan and increased resistance to oxidative stress and starvation.

Strain
rpr[UAS.C];dil[2]
Lifespan (days)
41.0
Lifespan change (compared to wild type)
20.59%
Phenotype
mNSC-ablated flies are long-lived and females show reduced fecundity.
Lifespan comparisons
Double mutant Lip2(DF);rpr(DF) has a lifespan of 41.0 days, while single mutant rpr(DF) has a lifespan of 35.0 days, single mutant Lip2(DF) has a lifespan of 37.0 days and wild type has a lifespan of 34.0 days.
Type of interaction
See methods
Synergistic (positive)
Citation
View abstract
Broughton SJ et al., 2005, Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands. Proc Natl Acad Sci U S A. 102(8):3105-10 15708981 Click here to select all mutants from this PubMed ID in the graph
Abstract
The insulin/insulin-like growth factor-like signaling pathway, present in all multicellular organisms, regulates diverse functions including growth, development, fecundity, metabolic homeostasis, and lifespan. In flies, ligands of the insulin/insulin-like growth factor-like signaling pathway, the Drosophila insulin-like peptides, regulate growth and hemolymph carbohydrate homeostasis during development and are expressed in a stage- and tissue-specific manner. Here, we show that ablation of Drosophila insulin-like peptide-producing median neurosecretory cells in the brain leads to increased fasting glucose levels in the hemolymph of adults similar to that found in diabetic mammals. They also exhibit increased storage of lipid and carbohydrate, reduced fecundity, and reduced tolerance of heat and cold. However, the ablated flies show an extension of median and maximal lifespan and increased resistance to oxidative stress and starvation.

Search genes: Lip2 rpr

Entrez ID
Symbol
GenAge
FlyBase ID

43980
Lip2
View on GenAge (Lip2)
FBgn0024740

Lipase 2

Locus: Dmel_CG17116

Entrez ID
Symbol
GenAge
FlyBase ID

40015
rpr
View on GenAge (rpr)
FBgn0011706

reaper

Locus: Dmel_CG4319

Orthologs of Lip2;rpr in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene

Orthologs of Lip2 in SynergyAge

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Species	Gene

Orthologs of rpr in SynergyAge

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Species	Gene