chico;ovo

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Genetic mutants with chico, ovo alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Strain
ovo[D1];P{ry11}chico1
Lifespan (days)
59.0
Lifespan change (compared to wild type)
34.09%
Phenotype
The chico homozygotes lived significantly longer than all other genotypes. In addition, the partially fertile chico 1 heterozygotes lived as long as the sterile flies that were heterozygous for both ovo D1 and chico 1 and lived significantly longer than the sterile ovo D1 heterozygotes.
Lifespan comparisons
Double mutant chico(DF);ovo(DF) has a lifespan of 59.0 days, while single mutant chico(DF) has a lifespan of 60.0 days, single mutant ovo(DF) has a lifespan of 50.0 days and wild type has a lifespan of 44.0 days.
Type of interaction
See methods
Dependent
Citation
View abstract
Clancy DJ et al., 2001, Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science. 292(5514):104-6 11292874 Click here to select all mutants from this PubMed ID in the graph
Abstract
The Drosophila melanogaster gene chico encodes an insulin receptor substrate that functions in an insulin/insulin-like growth factor (IGF) signaling pathway. In the nematode Caenorhabditis elegans, insulin/IGF signaling regulates adult longevity. We found that mutation of chico extends fruit fly median life-span by up to 48% in homozygotes and 36% in heterozygotes. Extension of life-span was not a result of impaired oogenesis in chico females, nor was it consistently correlated with increased stress resistance. The dwarf phenotype of chico homozygotes was also unnecessary for extension of life-span. The role of insulin/IGF signaling in regulating animal aging is therefore evolutionarily conserved.

Search genes: chico ovo

Entrez ID
Symbol
GenAge
FlyBase ID

64880
chico
View on GenAge (chico)
FBgn0024248

chico

Locus: Dmel_CG5686

Entrez ID
Symbol
GenAge
FlyBase ID

31429
ovo
View on GenAge (ovo)
FBgn0003028

ovo

Locus: Dmel_CG6824

Orthologs of chico;ovo in SynergyAge

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Orthologs of chico in SynergyAge

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Orthologs of ovo in SynergyAge

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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.