Lifespan changes: From wild type to chico;ovo DF = decrease in function; IF = increase in function

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Genetic mutants with chico, ovo alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Strain


  • Lifespan (days)


  • Lifespan change (compared to wild type)


  • Phenotype

    The chico homozygotes lived significantly longer than all other genotypes. In addition, the partially fertile chico 1 heterozygotes lived as long as the sterile flies that were heterozygous for both ovo D1 and chico 1 and lived significantly longer than the sterile ovo D1 heterozygotes.

  • Lifespan comparisons

    Double mutant chico(DF);ovo(DF) has a lifespan of 59.0 days, while single mutant chico(DF) has a lifespan of 60.0 days, single mutant ovo(DF) has a lifespan of 50.0 days and wild type has a lifespan of 44.0 days.

  • Type of interaction
    See methods


  • Citation
    View abstract

    Clancy DJ et al., 2001, Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science. 292(5514):104-6 PubMed 11292874 Click here to select all mutants from this PubMed ID in the graph

Search genes: chico ovo
  • Entrez ID
  • Symbol
  • GenAge
  • FlyBase ID


Locus: Dmel_CG5686

  • Entrez ID
  • Symbol
  • GenAge
  • FlyBase ID


Locus: Dmel_CG6824

Orthologs of chico;ovo in SynergyAge
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Species Gene
Orthologs of chico in SynergyAge
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Species Gene
Orthologs of ovo in SynergyAge
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Species Gene

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020).

Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

Group webpage: