Sod1;Sod1

There is no network for this step.

Fullscreen mode

Hide graph

Legend

Genetic mutants with Sod1, Sod1 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Strain
Sod1[1];Sod[X39]
Temperature °C
25
Diet
standard corn meal medium
Lifespan (days)
7.5
Lifespan comparisons
Double mutant Sod1(DF);Sod1(DF) has a lifespan of 7.5 days, while single mutant Sod1(DF) has a lifespan of 7.0 days and single mutant Sod1(DF) has a lifespan of 10.5 days.
Citation
View abstract
Ruan H, Wu CF, 2008, Social interaction-mediated lifespan extension of Drosophila Cu/Zn superoxide dismutase mutants. Proc Natl Acad Sci U S A. 105(21):7506-10 18508973 Click here to select all mutants from this PubMed ID in the graph
Abstract
Beneficial effects of social interaction on aging have been studied in humans and other species. We found that short-lived Drosophila mutants of the antioxidant enzyme Cu/Zn superoxide dismutase displayed a robust lifespan extension, with improved stress resistance and motor ability, upon cohousing with active flies of longer lifespan or younger age. Genetic, surgical, and environmental manipulations revealed motor and sensory components in behavioral interactions required for the lifespan extension induced by cohousing. Our results provide a definitive case of beneficial social interaction on lifespan and a useful entry point for analyzing the underlying molecular networks and physiological mechanisms.

Strain
Sod1[1];Sod[X39]
Temperature °C
25
Diet
standard corn meal medium
Lifespan (days)
21.0
Phenotype
Cohousing with w helpers conferred lifespan extension for the various Sod alleles and heteroallelic combinations.
Lifespan comparisons
Double mutant Sod1(DF);Sod1(DF) has a lifespan of 21.0 days, while single mutant Sod1(DF) has a lifespan of 13.5 days and single mutant Sod1(DF) has a lifespan of 21.0 days.
Citation
View abstract
Ruan H, Wu CF, 2008, Social interaction-mediated lifespan extension of Drosophila Cu/Zn superoxide dismutase mutants. Proc Natl Acad Sci U S A. 105(21):7506-10 18508973 Click here to select all mutants from this PubMed ID in the graph
Abstract
Beneficial effects of social interaction on aging have been studied in humans and other species. We found that short-lived Drosophila mutants of the antioxidant enzyme Cu/Zn superoxide dismutase displayed a robust lifespan extension, with improved stress resistance and motor ability, upon cohousing with active flies of longer lifespan or younger age. Genetic, surgical, and environmental manipulations revealed motor and sensory components in behavioral interactions required for the lifespan extension induced by cohousing. Our results provide a definitive case of beneficial social interaction on lifespan and a useful entry point for analyzing the underlying molecular networks and physiological mechanisms.

Strain
Sod1[n1];Sod[n64]
Temperature °C
23
Diet
standard corn meal medium
Lifespan (days)
3.5
Lifespan comparisons
Double mutant Sod1(DF);Sod1(DF) has a lifespan of 3.5 days, while single mutant Sod1(DF) has a lifespan of 10.5 days.
Citation
View abstract
Ruan H, Wu CF, 2008, Social interaction-mediated lifespan extension of Drosophila Cu/Zn superoxide dismutase mutants. Proc Natl Acad Sci U S A. 105(21):7506-10 18508973 Click here to select all mutants from this PubMed ID in the graph
Abstract
Beneficial effects of social interaction on aging have been studied in humans and other species. We found that short-lived Drosophila mutants of the antioxidant enzyme Cu/Zn superoxide dismutase displayed a robust lifespan extension, with improved stress resistance and motor ability, upon cohousing with active flies of longer lifespan or younger age. Genetic, surgical, and environmental manipulations revealed motor and sensory components in behavioral interactions required for the lifespan extension induced by cohousing. Our results provide a definitive case of beneficial social interaction on lifespan and a useful entry point for analyzing the underlying molecular networks and physiological mechanisms.

Strain
Sod1[n1];Sod[n64]
Temperature °C
23
Diet
standard corn meal medium
Lifespan (days)
16.5
Lifespan comparisons
Double mutant Sod1(DF);Sod1(DF) has a lifespan of 16.5 days, while single mutant Sod1(DF) has a lifespan of 21.0 days.
Citation
View abstract
Ruan H, Wu CF, 2008, Social interaction-mediated lifespan extension of Drosophila Cu/Zn superoxide dismutase mutants. Proc Natl Acad Sci U S A. 105(21):7506-10 18508973 Click here to select all mutants from this PubMed ID in the graph
Abstract
Beneficial effects of social interaction on aging have been studied in humans and other species. We found that short-lived Drosophila mutants of the antioxidant enzyme Cu/Zn superoxide dismutase displayed a robust lifespan extension, with improved stress resistance and motor ability, upon cohousing with active flies of longer lifespan or younger age. Genetic, surgical, and environmental manipulations revealed motor and sensory components in behavioral interactions required for the lifespan extension induced by cohousing. Our results provide a definitive case of beneficial social interaction on lifespan and a useful entry point for analyzing the underlying molecular networks and physiological mechanisms.

Strain
Sod[X39];Sod[n64]
Temperature °C
23
Diet
standard corn meal medium
Lifespan (days)
1.5
Lifespan comparisons
Double mutant Sod1(DF);Sod1(DF) has a lifespan of 1.5 days, while single mutant Sod1(DF) has a lifespan of 7.0 days.
Citation
View abstract
Ruan H, Wu CF, 2008, Social interaction-mediated lifespan extension of Drosophila Cu/Zn superoxide dismutase mutants. Proc Natl Acad Sci U S A. 105(21):7506-10 18508973 Click here to select all mutants from this PubMed ID in the graph
Abstract
Beneficial effects of social interaction on aging have been studied in humans and other species. We found that short-lived Drosophila mutants of the antioxidant enzyme Cu/Zn superoxide dismutase displayed a robust lifespan extension, with improved stress resistance and motor ability, upon cohousing with active flies of longer lifespan or younger age. Genetic, surgical, and environmental manipulations revealed motor and sensory components in behavioral interactions required for the lifespan extension induced by cohousing. Our results provide a definitive case of beneficial social interaction on lifespan and a useful entry point for analyzing the underlying molecular networks and physiological mechanisms.

Strain
Sod[X39];Sod[n64]
Temperature °C
23
Diet
standard corn meal medium
Lifespan (days)
7.5
Lifespan comparisons
Double mutant Sod1(DF);Sod1(DF) has a lifespan of 7.5 days, while single mutant Sod1(DF) has a lifespan of 13.5 days.
Citation
View abstract
Ruan H, Wu CF, 2008, Social interaction-mediated lifespan extension of Drosophila Cu/Zn superoxide dismutase mutants. Proc Natl Acad Sci U S A. 105(21):7506-10 18508973 Click here to select all mutants from this PubMed ID in the graph
Abstract
Beneficial effects of social interaction on aging have been studied in humans and other species. We found that short-lived Drosophila mutants of the antioxidant enzyme Cu/Zn superoxide dismutase displayed a robust lifespan extension, with improved stress resistance and motor ability, upon cohousing with active flies of longer lifespan or younger age. Genetic, surgical, and environmental manipulations revealed motor and sensory components in behavioral interactions required for the lifespan extension induced by cohousing. Our results provide a definitive case of beneficial social interaction on lifespan and a useful entry point for analyzing the underlying molecular networks and physiological mechanisms.

Search genes: Sod1 Sod1

Entrez ID
Symbol
GenAge
FlyBase ID

39251
Sod1
View on GenAge (Sod1)
FBgn0003462

Superoxide dismutase 1

Locus: Dmel_CG11793

Entrez ID
Symbol
GenAge
FlyBase ID

39251
Sod1
View on GenAge (Sod1)
FBgn0003462

Superoxide dismutase 1

Locus: Dmel_CG11793

Orthologs of Sod1;Sod1 in SynergyAge

Show in SynergyAge
Species	Gene
Caenorhabditis elegans	sod-1;sod-5

Not in SynergyAge
Species	Gene
Caenorhabditis elegans	sod-1;sod-1
Caenorhabditis elegans	sod-5;sod-5
Mus musculus	Sod1;Sod1

Orthologs of Sod1 in SynergyAge

Show in SynergyAge
Species	Gene
Caenorhabditis elegans	sod-1
Caenorhabditis elegans	sod-5
Mus musculus	Sod1

Not in SynergyAge
Species	Gene