sun;y

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Genetic mutants with sun, y alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Strain
sun[EM67];yw[67c23]
Temperature °C
25
Diet
standard cornmeal and agar medium
Lifespan (days)
64.0
Lifespan change (compared to wild type)
60.00%
Phenotype
The increase in lifespan of sun mutants was observed in sun EM67 in w/yw 67c23.
Lifespan comparisons
Double mutant sun(DF);y(IF) has a lifespan of 64.0 days, while single mutant y(IF) has a lifespan of 56.0 days, single mutant sun(DF) has a lifespan of 50.0 days and wild type has a lifespan of 40.0 days.
Type of interaction
See methods
Almost additive (positive)
Citation
View abstract
Cvejic S et al., 2004, The endogenous ligand Stunted of the GPCR Methuselah extends lifespan in Drosophila. Nat Cell Biol. 6(6):540-6 15133470 Click here to select all mutants from this PubMed ID in the graph
Abstract
Many extracellular signals are transmitted to the interior of the cell by receptors with seven membrane-spanning helices that trigger their effects by means of heterotrimeric guanine-nucleotide-binding regulatory proteins (G proteins). These G-protein-coupled receptors (GPCRs) control various physiological functions in evolution from pheromone-induced mating in yeast to cognition in humans. The potential role of the G-protein signalling system in the control of animal ageing has been highlighted by the genetic revelation that mutation of a GPCR encoded by methuselah extends the lifespan of adult Drosophila flies. How methuselah functions in controlling ageing is not clear. A first essential step towards the understanding of methuselah function is to determine the ligands of Methuselah. Here we report the identification and characterization of two endogenous peptide ligands of Methuselah, designated Stunted A and B. Flies with mutations in the gene encoding these ligands show an increase in lifespan and resistance to oxidative stress. We conclude that the Stunted-Methuselah system is involved in the control of animal ageing.

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Strain
P{11.6-[3']-S/S};yw[67c23]
Temperature °C
25
Diet
standard cornmeal and agar medium
Lifespan (days)
49.6
Lifespan change (compared to wild type)
24.00%
Phenotype
w /yw 67c23 ; +/pW8gDmM-Sal(3 ' ) female progeny were used to examine whether additional copies of the sun gene could by itself affect the lifespan of Drosophila. An increase in lifespan was not observed in other heterozygotes, such as pW8gDmM-Sal(3 ' ) in w/yw 67c23.
Lifespan comparisons
Double mutant sun(IF);y(IF) has a lifespan of 49.6 days, while single mutant y(IF) has a lifespan of 56.0 days and wild type has a lifespan of 40.0 days.
Type of interaction
See methods
Contains dependence
Citation
View abstract
Cvejic S et al., 2004, The endogenous ligand Stunted of the GPCR Methuselah extends lifespan in Drosophila. Nat Cell Biol. 6(6):540-6 15133470 Click here to select all mutants from this PubMed ID in the graph
Abstract
Many extracellular signals are transmitted to the interior of the cell by receptors with seven membrane-spanning helices that trigger their effects by means of heterotrimeric guanine-nucleotide-binding regulatory proteins (G proteins). These G-protein-coupled receptors (GPCRs) control various physiological functions in evolution from pheromone-induced mating in yeast to cognition in humans. The potential role of the G-protein signalling system in the control of animal ageing has been highlighted by the genetic revelation that mutation of a GPCR encoded by methuselah extends the lifespan of adult Drosophila flies. How methuselah functions in controlling ageing is not clear. A first essential step towards the understanding of methuselah function is to determine the ligands of Methuselah. Here we report the identification and characterization of two endogenous peptide ligands of Methuselah, designated Stunted A and B. Flies with mutations in the gene encoding these ligands show an increase in lifespan and resistance to oxidative stress. We conclude that the Stunted-Methuselah system is involved in the control of animal ageing.

Search genes: sun y

Entrez ID
Symbol
GenAge
FlyBase ID

44046
sun
View on GenAge (sun)
FBgn0014391

stunted

Locus: Dmel_CG9032

Entrez ID
Symbol
GenAge
FlyBase ID

30980
y
View on GenAge (y)
FBgn0004034

yellow

Locus: Dmel_CG3757

Orthologs of sun;y in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene

Orthologs of sun in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Caenorhabditis elegans	hpo-18
Caenorhabditis elegans	R05D3.6
Caenorhabditis elegans	ZC262.5
Mus musculus	Atp5e

Orthologs of y in SynergyAge

Show in SynergyAge
Species	Gene