Lifespan changes: From wild type to trpa-1;unc-43

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Genetic mutants with trpa-1, unc-43 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C


  • Diet


  • Lifespan (days)


  • Lifespan change (compared to wild type)


  • Phenotype

    trpa-1 transgene can further extend the lifespan of unk-43 mutant worms.

  • Lifespan comparisons

    Double mutant trpa-1(xuEx601);unc-43(n498) has a lifespan of 22.41 days, while single mutant trpa-1(xuEx601) has a lifespan of 22.41 days, single mutant unc-43(n498) has a lifespan of 19.31 days and wild type has a lifespan of 19.65 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Xiao R et al., 2013, A genetic program promotes C. elegans longevity at cold temperatures via a thermosensitive TRP channel. Cell. 152(4):806-17 PubMed 23415228 Click here to select all mutants from this PubMed ID in the graph

Search genes: trpa-1 unc-43
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

TRPA cation channel homolog;Transient receptor potential cation channel subfamily A member 1 homolog

Locus: CELE_C29E6.2

Wormbase description: trpa-1 encodes a transient receptor potential (TRP) ion channel orthologous to the vertebrate and Drosophila TRPA1 channels; in C. elegans, trpa-1 activity is required for specific mechanosensory behaviors such as nose-touch avoidance and touch-mediated foraging; when expressed in mammalian cells, TRPA-1 exhibits channel activity in response to mechanical stimulation; TRPA-1::GFP reporters are expressed in a number of different cell types including sensory neurons, muscle, and epithelial cells.

  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Calcium/calmodulin-dependent protein kinase type II;hypothetical protein

Locus: CELE_K11E8.1

Wormbase description: unc-43 encodes the C. elegans ortholog of type II calcium/calmodulin-dependent protein kinase (CaMKII); unc-43 activity is required for a number of processes, including locomotion, neuronal cell fate specification and regulation of synaptic density, egg laying, defecation, and meiotic maturation; in regulating some of these processes, unc-43 acts in concert with MAPKKK and G protein signaling pathways; UNC-43 is expressed in neurons, oocytes, and gonadal sheath cells; UNC-43 can regulate the activity of the EGL-2 ether-a-go-go potassium channel with which it physically interacts.

Orthologs of trpa-1;unc-43 in SynergyAge
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Species Gene
Orthologs of trpa-1 in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of unc-43 in SynergyAge
Show in SynergyAge
Species Gene

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020).

Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

Group webpage: