sgk-1;trpa-1

Lifespan changes: From wild type to sgk-1;trpa-1

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Genetic mutants with sgk-1, trpa-1 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    20

  • Diet

    NGM

  • Lifespan (days)

    15.8

  • Lifespan change (compared to wild type)

    -19.39%

  • Phenotype

    Loss of sgk-1 fully suppresses the long-lived phenotype of trpa-1 and pkc-2 transgenic animals.

  • Lifespan comparisons

    Double mutant sgk-1(ok538);trpa-1(xuEx601) has a lifespan of 15.8 days, while single mutant trpa-1(xuEx601) has a lifespan of 25.2 days, single mutant sgk-1(ok538) has a lifespan of 15.6 days and wild type has a lifespan of 19.6 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Xiao R et al., 2013, A genetic program promotes C. elegans longevity at cold temperatures via a thermosensitive TRP channel. Cell. 152(4):806-17 PubMed 23415228 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    20

  • Diet

    NGM

  • Lifespan (days)

    18.7

  • Lifespan change (compared to wild type)

    -5.08%

  • Phenotype

    Loss of sgk-1 fully suppresses the long-lived phenotype of trpa-1 and pkc-2 transgenic animals.

  • Lifespan comparisons

    Double mutant sgk-1(ok538);trpa-1(xuEx601) has a lifespan of 18.7 days, while single mutant trpa-1(xuEx601) has a lifespan of 25.1 days, single mutant sgk-1(ok538) has a lifespan of 17.4 days and wild type has a lifespan of 19.7 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Xiao R et al., 2013, A genetic program promotes C. elegans longevity at cold temperatures via a thermosensitive TRP channel. Cell. 152(4):806-17 PubMed 23415228 Click here to select all mutants from this PubMed ID in the graph

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    20

  • Diet

    NGM

  • Lifespan (days)

    25.27

  • Lifespan change (compared to wild type)

    22.97%

  • Phenotype

    sgk-1 transgene can fully suppress the short-lived phenotype of trpa-1mutant worms, consistent with the model that SGK-1 acts downstream of TRPA-1.

  • Lifespan comparisons

    Double mutant sgk-1(xuEx1266);trpa-1(ok999) has a lifespan of 25.27 days, while single mutant sgk-1(xuEx1266) has a lifespan of 25.27 days, single mutant trpa-1(ok999) has a lifespan of 17.5 days and wild type has a lifespan of 20.55 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Xiao R et al., 2013, A genetic program promotes C. elegans longevity at cold temperatures via a thermosensitive TRP channel. Cell. 152(4):806-17 PubMed 23415228 Click here to select all mutants from this PubMed ID in the graph

Search genes: sgk-1 trpa-1
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Serine/threonine-protein kinase sgk-1


Locus: CELE_W10G6.2


Wormbase description: sgk-1 encodes a serine/threonine protein kinase that is orthologous to the mammalian serum- and glucocorticoid-inducible kinases (SGKs); in C. elegans, sgk-1 activity is required for normal egg laying, generation time, stress response, and adult life span; SGK-1 forms a complex with the AKT kinases with which it functions in parallel to mediate certain aspects of DAF-2/insulin-signaling; SGK-1 phosphorylates DAF-16 in vitro in a manner strictly dependent upon pdk-1 which encodes a 3-phosphoinositide-dependent kinase; an SGK-1::GFP fusion protein is expressed beginning in late embryonic stages and in larvae is seen in sensory and motor neurons as well as in the intestine; in neurons SGK-1::GFP localizes to the cytoplasm and the nucleus, while in the intestine SGK-1::GFP is found exclusively in the cytoplasm.


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

TRPA cation channel homolog;Transient receptor potential cation channel subfamily A member 1 homolog


Locus: CELE_C29E6.2


Wormbase description: trpa-1 encodes a transient receptor potential (TRP) ion channel orthologous to the vertebrate and Drosophila TRPA1 channels; in C. elegans, trpa-1 activity is required for specific mechanosensory behaviors such as nose-touch avoidance and touch-mediated foraging; when expressed in mammalian cells, TRPA-1 exhibits channel activity in response to mechanical stimulation; TRPA-1::GFP reporters are expressed in a number of different cell types including sensory neurons, muscle, and epithelial cells.


Orthologs of sgk-1;trpa-1 in SynergyAge
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Orthologs of sgk-1 in SynergyAge
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Orthologs of trpa-1 in SynergyAge
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About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Contact
Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania
Email:

Group webpage: www.aging-research.group