daf-15;dpy-20

Genetic mutants with daf-15, dpy-20 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
25
Lifespan (days)
16.4
Lifespan change (compared to wild type)
30.16%
Lifespan comparisons
Double mutant daf-15(m81);dpy-20(e1282) has a lifespan of 16.4 days, while wild type has a lifespan of 12.6 days.
Citation
View abstract
Jia K et al., 2004, The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span. Development. 131(16):3897-906 15253933 Click here to select all mutants from this PubMed ID in the graph
Abstract
The highly conserved target-of-rapamycin (TOR) protein kinases control cell growth in response to nutrients and growth factors. In mammals, TOR has been shown to interact with raptor to relay nutrient signals to downstream translation machinery. We report that in C. elegans, mutations in the genes encoding CeTOR and raptor result in dauer-like larval arrest, implying that CeTOR regulates dauer diapause. The daf-15 (raptor) and let-363 (CeTOR) mutants shift metabolism to accumulate fat, and raptor mutations extend adult life span. daf-15 transcription is regulated by DAF-16, a FOXO transcription factor that is in turn regulated by daf-2 insulin/IGF signaling. This is a new mechanism that regulates the TOR pathway. Thus, DAF-2 insulin/IGF signaling and nutrient signaling converge on DAF-15 (raptor) to regulate C. elegans larval development, metabolism and life span.

Search genes: daf-15 dpy-20

Entrez ID
Symbol
GenAge
Wormbase ID

177770
daf-15
View on GenAge (daf-15)
WBGene00000911

hypothetical protein

Locus: CELE_C10C5.6

Wormbase description: daf-15 encodes an ortholog of RAPTOR (the regulatory associated protein of mTOR), and is regulated by DAF-16; daf-15 is required for non-dauer development, at least in some tissues or stages; daf-15(m81) mutants constitutively and irreversibly form abnormal dauer-like larvae (and are thus effectively lethal/sterile); mutants do not form true dauers when exposed to dauer pheromone, yet execute only two molts.

Entrez ID
Symbol
GenAge
Wormbase ID

178105
dpy-20
View on GenAge (dpy-20)
WBGene00001079

Protein dumpy-20

Locus: CELE_T22B3.1

Wormbase description: dpy-20 encodes a BED zinc finger protein, with no known homologs outside of nematodes, that is required for normal body morphology.

Orthologs of daf-15;dpy-20 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene

Orthologs of daf-15 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	raptor

Orthologs of dpy-20 in SynergyAge

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Species	Gene

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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.