Lifespan changes: From wild type to aha-1;tpk-1

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Genetic mutants with aha-1, tpk-1 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C


  • Diet


  • Lifespan (days)


  • Lifespan comparisons

    Double mutant aha-1(RNAi);tpk-1(qm162) has a lifespan of 28.86 days, while single mutant tpk-1(qm162) has a lifespan of 32.15 days.

  • Citation
    View abstract

    Khan MH et al., 2013, TAF-4 is required for the life extension of isp-1, clk-1 and tpk-1 Mit mutants. Aging (Albany NY). 5(10):741-58 PubMed 24107417 Click here to select all mutants from this PubMed ID in the graph

Search genes: aha-1 tpk-1
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Aryl hydrocarbon receptor nuclear translocator homolog

Locus: CELE_C25A1.11

Wormbase description: aha-1 encodes an ortholog of human aryl-hydrocarbon receptor nuclear translocator; AHA-1 interacts with AHR-1 and HIF-1 in vitro, requires HIF-1 for proper localization, and is expressed ubiquitously; AHA-1 also physically interacts with CKY-1, and when co-expressed in vitro, an AHA-1/CKY-1 complex exhibits sequence-specific DNA binding; when co-expressed in cultured cells, the AHA-1/CKY-1 complex can stimulate reporter gene transcription;

  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Thiamin pyrophosphokinase 1

Locus: CELE_ZK637.9

Wormbase description: none available

Orthologs of aha-1;tpk-1 in SynergyAge
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Species Gene
Orthologs of aha-1 in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of tpk-1 in SynergyAge
Show in SynergyAge
Species Gene

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

Group webpage: www.aging-research.group