Lifespan changes: From wild type to aha-1;clk-1

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Genetic mutants with aha-1, clk-1 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C


  • Lifespan (days)


  • Phenotype

    The long lifespan of clk-1(qm30) mutants was significantly shortened by aha-1 [HIF1 beta] RNAi.

  • Lifespan comparisons

    Double mutant aha-1(RNAi);clk-1(qm30) has a lifespan of 15.3 days, while single mutant aha-1(RNAi) has a lifespan of 15.2 days, single mutant clk-1(qm30) has a lifespan of 21.4 days and wild type has a lifespan of 15.3 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Lee SJ et al., 2010, Inhibition of respiration extends C. elegans life span via reactive oxygen species that increase HIF-1 activity. Curr Biol. 20(23):2131-6 PubMed 21093262 Click here to select all mutants from this PubMed ID in the graph

Search genes: aha-1 clk-1
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Aryl hydrocarbon receptor nuclear translocator homolog

Locus: CELE_C25A1.11

Wormbase description: aha-1 encodes an ortholog of human aryl-hydrocarbon receptor nuclear translocator; AHA-1 interacts with AHR-1 and HIF-1 in vitro, requires HIF-1 for proper localization, and is expressed ubiquitously; AHA-1 also physically interacts with CKY-1, and when co-expressed in vitro, an AHA-1/CKY-1 complex exhibits sequence-specific DNA binding; when co-expressed in cultured cells, the AHA-1/CKY-1 complex can stimulate reporter gene transcription;

  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

5-demethoxyubiquinone hydroxylase, mitochondrial

Locus: CELE_ZC395.2

Wormbase description: clk-1 encodes the C. elegans ortholog of COQ7/CAT5, a highly conserved demethoxyubiquinone (DMQ) hydroxylase that is necessary for the biosynthesis of ubiquinone (coenzyme Q, Q9) from 5-demethoxyubiquinone (DMQ9); in C. elegans, CLK-1 activity is required for normal physiological rates of growth, development, behavior, and aging, as well as for normal brood sizes.

Orthologs of aha-1;clk-1 in SynergyAge
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Species Gene
Orthologs of aha-1 in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of clk-1 in SynergyAge
Show in SynergyAge
Species Gene

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

Group webpage: www.aging-research.group