atg-18;mes-1

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Genetic mutants with atg-18, mes-1 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Diet
OP50; HT115E
Lifespan (days)
12.2
Lifespan change (compared to wild type)
-26.51%
Phenotype
RNAi inhibition ofatg-18 significantly reduced the mean lifespan of germline-deficient mutant, mes-1(bn7).
Lifespan comparisons
Double mutant atg-18(RNAi);mes-1(bn17) has a lifespan of 12.2 days, while single mutant atg-18(RNAi) has a lifespan of 16.1 days, single mutant mes-1(bn17) has a lifespan of 17.5 days and wild type has a lifespan of 16.6 days.
Type of interaction
See methods
Opposite lifespan effects of single mutants
Citation
View abstract
Lapierre LR et al., 2011, Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans. Curr Biol. 21(18):1507-14 21906946 Click here to select all mutants from this PubMed ID in the graph
Abstract
The cellular recycling process of autophagy is emerging as a key player in several longevity pathways in Caenorhabditis elegans. Here, we identify a role for autophagy in long-lived animals lacking a germline and show that autophagy and lipid metabolism work interdependently to modulate aging in this longevity model.

Search genes: atg-18 mes-1

Entrez ID
Symbol
GenAge
Wormbase ID

179246
atg-18
View on GenAge (atg-18)
WBGene00018294

AuTophaGy (yeast Atg homolog)

Locus: CELE_F41E6.13

Wormbase description: atg-18 encodes, by alternative splicing, two isoforms of a WD40 repeat-containing protein orthologous to the autophagic budding yeast protein Atg18p, and to human WIPI1 (OMIM:609224) and WIPI2 (OMIM:609225); ATG-18 activity is essential for normal dauer morphogenesis and autophagy in daf-2 mutant animals; ATG-18 is expressed in larval and adult pharynx, bodywall muscle, hypodermis, seam cells, and neurons, and in larval intestine; in mass RNAi assays, ATG-18 is required for normally rapid growth, and is weakly required for the viability of cup-5(ar465) mutants.

Entrez ID
Symbol
GenAge
Wormbase ID

181362
mes-1
View on GenAge (mes-1)
WBGene00003219

Protein mes-1

Locus: CELE_F54F7.5

Wormbase description: The mes-1 gene encodes a receptor tyrosine kinase-like protein that is required for unequal cell divisions in the early embryonic germline; during embryonic cell divisions, mes-1 is involved in positioning of the early mitotic spindle and of associated P granules.

Orthologs of atg-18;mes-1 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene

Orthologs of atg-18 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	Atg18b
Drosophila melanogaster	Atg18a
Mus musculus	Wipi2
Mus musculus	Wipi1

Orthologs of mes-1 in SynergyAge

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Species	Gene

About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.