ife-2;rps-15

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Genetic mutants with ife-2, rps-15 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Lifespan (days)
22.4
Phenotype
The lifespans of S6K/rsks-1(sv31) and eIF4E/ife-2(ok306) mutants subjected to TOR RNAi were longer than the lifespans of either the S6K or eIF4E mutant alone
Lifespan comparisons
Double mutant ife-2(ok306);rps-15(RNAi) has a lifespan of 22.4 days, while single mutant ife-2(ok306) has a lifespan of 19.6 days.
Citation
View abstract
Hansen M et al., 2007, Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell. 6(1):95-110 17266679 Click here to select all mutants from this PubMed ID in the graph
Abstract
Many conditions that shift cells from states of nutrient utilization and growth to states of cell maintenance extend lifespan. We have carried out a systematic lifespan analysis of conditions that inhibit protein synthesis. We find that reducing the levels of ribosomal proteins, ribosomal-protein S6 kinase or translation-initiation factors increases the lifespan of Caenorhabditis elegans. These perturbations, as well as inhibition of the nutrient sensor target of rapamycin (TOR), which is known to increase lifespan, all increase thermal-stress resistance. Thus inhibiting translation may extend lifespan by shifting cells to physiological states that favor maintenance and repair. Interestingly, different types of translation inhibition lead to one of two mutually exclusive outputs, one that increases lifespan and stress resistance through the transcription factor DAF-16/FOXO, and one that increases lifespan and stress resistance independently of DAF-16. Our findings link TOR, but not sir-2.1, to the longevity response induced by dietary restriction (DR) in C. elegans, and they suggest that neither TOR inhibition nor DR extends lifespan simply by reducing protein synthesis.

Temperature °C
20
Lifespan (days)
23.5
Phenotype
The lifespans of S6K/rsks-1(sv31) and eIF4E/ife-2(ok306) mutants subjected to TOR RNAi were longer than the lifespans of either the S6K or eIF4E mutant alone
Lifespan comparisons
Double mutant ife-2(ok306);rps-15(RNAi) has a lifespan of 23.5 days, while single mutant ife-2(ok306) has a lifespan of 20.8 days.
Citation
View abstract
Hansen M et al., 2007, Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell. 6(1):95-110 17266679 Click here to select all mutants from this PubMed ID in the graph
Abstract
Many conditions that shift cells from states of nutrient utilization and growth to states of cell maintenance extend lifespan. We have carried out a systematic lifespan analysis of conditions that inhibit protein synthesis. We find that reducing the levels of ribosomal proteins, ribosomal-protein S6 kinase or translation-initiation factors increases the lifespan of Caenorhabditis elegans. These perturbations, as well as inhibition of the nutrient sensor target of rapamycin (TOR), which is known to increase lifespan, all increase thermal-stress resistance. Thus inhibiting translation may extend lifespan by shifting cells to physiological states that favor maintenance and repair. Interestingly, different types of translation inhibition lead to one of two mutually exclusive outputs, one that increases lifespan and stress resistance through the transcription factor DAF-16/FOXO, and one that increases lifespan and stress resistance independently of DAF-16. Our findings link TOR, but not sir-2.1, to the longevity response induced by dietary restriction (DR) in C. elegans, and they suggest that neither TOR inhibition nor DR extends lifespan simply by reducing protein synthesis.

Search genes: ife-2 rps-15

Entrez ID
Symbol
GenAge
Wormbase ID

180393
ife-2
View on GenAge (ife-2)
WBGene00002060

Eukaryotic translation initiation factor 4E-2

Locus: CELE_R04A9.4

Wormbase description: ife-2 encodes a translation initiation factor 4F, cap-binding subunit (eIF-4E); by homology, IFE-2 is predicted to function in cap-dependent mRNA translation initiation; loss of ife-2 activity in adult animals extends lifespan.

Entrez ID
Symbol
GenAge
Wormbase ID

172693
rps-15
View on GenAge (rps-15)
WBGene00004484

40S ribosomal protein S15

Locus: CELE_F36A2.6

Wormbase description: rps-15 encodes a small ribosomal subunit S15 protein.

Orthologs of ife-2;rps-15 in SynergyAge

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Species	Gene

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Species	Gene

Orthologs of ife-2 in SynergyAge

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Species	Gene

Orthologs of rps-15 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	RpS15
Mus musculus	Rps15