bec-1;LPL-4

There is no network for this step.

Fullscreen mode

Hide graph

Legend

Genetic mutants with bec-1, LPL-4 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Diet
OP50; HT115E
Lifespan (days)
20.4
Lifespan change (compared to wild type)
6.25%
Phenotype
RNAi-mediated inhibition of bec-1 significantly reduced the lifespan of LIPL-4 overexpressing animals, while having negligible effects on non-transgenic siblings.
Lifespan comparisons
Double mutant bec-1(RNAi);LPL-4(OE) has a lifespan of 20.4 days, while single mutant bec-1(RNAi) has a lifespan of 20.2 days, single mutant LPL-4(OE) has a lifespan of 24.0 days and wild type has a lifespan of 19.2 days.
Type of interaction
See methods
Dependent
Citation
View abstract
Lapierre LR et al., 2011, Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans. Curr Biol. 21(18):1507-14 21906946 Click here to select all mutants from this PubMed ID in the graph
Abstract
The cellular recycling process of autophagy is emerging as a key player in several longevity pathways in Caenorhabditis elegans. Here, we identify a role for autophagy in long-lived animals lacking a germline and show that autophagy and lipid metabolism work interdependently to modulate aging in this longevity model.

Temperature °C
20
Diet
OP50; HT115E
Lifespan (days)
17.2
Lifespan change (compared to wild type)
-6.52%
Phenotype
RNAi-mediated inhibition of bec-1 significantly reduced the lifespan of LIPL-4 overexpressing animals, while having negligible effects on non-transgenic siblings.
Lifespan comparisons
Double mutant bec-1(RNAi);LPL-4(OE) has a lifespan of 17.2 days, while single mutant bec-1(RNAi) has a lifespan of 19.2 days, single mutant LPL-4(OE) has a lifespan of 22.7 days and wild type has a lifespan of 18.4 days.
Type of interaction
See methods
Antagonistic (negative)
Citation
View abstract
Lapierre LR et al., 2011, Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans. Curr Biol. 21(18):1507-14 21906946 Click here to select all mutants from this PubMed ID in the graph
Abstract
The cellular recycling process of autophagy is emerging as a key player in several longevity pathways in Caenorhabditis elegans. Here, we identify a role for autophagy in long-lived animals lacking a germline and show that autophagy and lipid metabolism work interdependently to modulate aging in this longevity model.

Temperature °C
20
Diet
OP50; HT115E
Lifespan (days)
18.6
Lifespan change (compared to wild type)
0.54%
Phenotype
RNAi-mediated inhibition of bec-1 significantly reduced the lifespan of LIPL-4 overexpressing animals, while having negligible effects on non-transgenic siblings.
Lifespan comparisons
Double mutant bec-1(RNAi);LPL-4(OE) has a lifespan of 18.6 days, while single mutant bec-1(RNAi) has a lifespan of 18.3 days, single mutant LPL-4(OE) has a lifespan of 21.4 days and wild type has a lifespan of 18.5 days.
Type of interaction
See methods
Opposite lifespan effects of single mutants
Citation
View abstract
Lapierre LR et al., 2011, Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans. Curr Biol. 21(18):1507-14 21906946 Click here to select all mutants from this PubMed ID in the graph
Abstract
The cellular recycling process of autophagy is emerging as a key player in several longevity pathways in Caenorhabditis elegans. Here, we identify a role for autophagy in long-lived animals lacking a germline and show that autophagy and lipid metabolism work interdependently to modulate aging in this longevity model.

Search genes: bec-1 LPL-4

Entrez ID
Symbol
GenAge
Wormbase ID

177345
bec-1
View on GenAge (bec-1)
WBGene00000247

Beclin homolog

Locus: CELE_T19E7.3

Wormbase description: bec-1 encodes a coiled-coil protein orthologous to the yeast and mammalian autophagy proteins Atg6/Vps30/Beclin1; by homology, BEC-1 may be part of a Class III phosphatidylinositol 3-kinase complex that plays a role in localizing autophagy proteins to preautophagosomal structures and overexpression of C. elegans bec-1 in S. cerevisiae APG6/VPS30 mutants can rescue associated autophagy defects; bec-1 is also required for regulation of endocytic retrograde transport; in C. elegans, bec-1 activity is required for normal dauer morphogenesis and survival of dauer larvae, as well as for adult life span extension of daf-2(e1370) mutants at 15 degrees; in addition, bec-1(RNAi) indicates a role for bec-1 in normal growth rates, movement, and vulval morphogenesis; a bec-1::GFP reporter fusion is expressed in the hypodermis, intestine, nervous system, pharynx, and reproductive organs, all tissues that are remodeled during dauer larval development.

Symbol
GenAge

LPL-4
View on GenAge (LPL-4)

No gene information for LPL-4

Orthologs of bec-1;LPL-4 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene

Orthologs of bec-1 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	Atg6
Mus musculus	Becn1

Orthologs of LPL-4 in SynergyAge

Show in SynergyAge
Species	Gene