lgg-1;LPL-4

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Genetic mutants with lgg-1, LPL-4 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Diet
OP50; HT115E
Lifespan (days)
15.8
Lifespan change (compared to wild type)
-12.22%
Phenotype
RNAi-mediated inhibition of lgg-1 significantly reduced the lifespan of LIPL-4 overexpressing animals, while having negligible effects on non-transgenic siblings.
Lifespan comparisons
Double mutant lgg-1(RNAi);LPL-4(OE) has a lifespan of 15.8 days, while single mutant lgg-1(RNAi) has a lifespan of 17.8 days, single mutant LPL-4(OE) has a lifespan of 19.2 days and wild type has a lifespan of 18.0 days.
Type of interaction
See methods
Opposite lifespan effects of single mutants
Citation
View abstract
Lapierre LR et al., 2011, Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans. Curr Biol. 21(18):1507-14 21906946 Click here to select all mutants from this PubMed ID in the graph
Abstract
The cellular recycling process of autophagy is emerging as a key player in several longevity pathways in Caenorhabditis elegans. Here, we identify a role for autophagy in long-lived animals lacking a germline and show that autophagy and lipid metabolism work interdependently to modulate aging in this longevity model.

Temperature °C
20
Diet
OP50; HT115E
Lifespan (days)
16.7
Lifespan change (compared to wild type)
-9.24%
Phenotype
RNAi-mediated inhibition of lgg-1 significantly reduced the lifespan of LIPL-4 overexpressing animals, while having negligible effects on non-transgenic siblings.
Lifespan comparisons
Double mutant lgg-1(RNAi);LPL-4(OE) has a lifespan of 16.7 days, while single mutant lgg-1(RNAi) has a lifespan of 19.8 days, single mutant LPL-4(OE) has a lifespan of 22.7 days and wild type has a lifespan of 18.4 days.
Type of interaction
See methods
Antagonistic (negative)
Citation
View abstract
Lapierre LR et al., 2011, Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans. Curr Biol. 21(18):1507-14 21906946 Click here to select all mutants from this PubMed ID in the graph
Abstract
The cellular recycling process of autophagy is emerging as a key player in several longevity pathways in Caenorhabditis elegans. Here, we identify a role for autophagy in long-lived animals lacking a germline and show that autophagy and lipid metabolism work interdependently to modulate aging in this longevity model.

Temperature °C
20
Diet
OP50; HT115E
Lifespan (days)
18.5
Phenotype
RNAi-mediated inhibition of lgg-1 significantly reduced the lifespan of LIPL-4 overexpressing animals, while having negligible effects on non-transgenic siblings.
Lifespan comparisons
Double mutant lgg-1(RNAi);LPL-4(OE) has a lifespan of 18.5 days, while single mutant lgg-1(RNAi) has a lifespan of 18.3 days, single mutant LPL-4(OE) has a lifespan of 21.4 days and wild type has a lifespan of 18.5 days.
Type of interaction
See methods
Opposite lifespan effects of single mutants
Citation
View abstract
Lapierre LR et al., 2011, Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans. Curr Biol. 21(18):1507-14 21906946 Click here to select all mutants from this PubMed ID in the graph
Abstract
The cellular recycling process of autophagy is emerging as a key player in several longevity pathways in Caenorhabditis elegans. Here, we identify a role for autophagy in long-lived animals lacking a germline and show that autophagy and lipid metabolism work interdependently to modulate aging in this longevity model.

Search genes: lgg-1 LPL-4

Entrez ID
Symbol
GenAge
Wormbase ID

174050
lgg-1
View on GenAge (lgg-1)
WBGene00002980

Protein lgg-1

Locus: CELE_C32D5.9

Wormbase description: lgg-1 encodes the C. elegans ortholog of Saccharomyces cerevisiae Atg8p and mammalian MAP-LC3; by homology, LGG-1 is predicted to be required for the degradation of cellular components by autophagy; loss of lgg-1 function via RNAi indicates that, like several other C. elegans genes involved in autophagy, lgg-1 is essential for normal dauer morphogenesis and life-span extension; a GFP::LGG-1 reporter fusion protein is expression in several different stages of development in multiple tissues, including the nervous system, pharynx, intestine, hypodermis, somatic gonad and vulva; under normal growth conditions, GFP::LGG-1 shows a diffuse cytoplasmic localization, but during dauer formation and in long-lived animals, GFP::LGG-1 shows a marked increase in punctate staining in hypodermal seam cells that likely reflects an increase in the number of preautophagosomal and autophagosomal structures.

Symbol
GenAge

LPL-4
View on GenAge (LPL-4)

No gene information for LPL-4

Orthologs of lgg-1;LPL-4 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene

Orthologs of lgg-1 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	Atg8a
Mus musculus	Gabarapl1
Mus musculus	Gabarap

Orthologs of LPL-4 in SynergyAge

Show in SynergyAge
Species	Gene