LPL-4;pha-4

There is no network for this step.

Fullscreen mode

Hide graph

Legend

Genetic mutants with LPL-4, pha-4 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Diet
OP50; HT115E
Lifespan (days)
18.9
Lifespan change (compared to wild type)
-0.53%
Phenotype
RNAi-mediated inhibition of pha-4 significantly reduced the lifespan of LIPL-4 overexpressing animals, while having negligible effects on non-transgenic siblings.
Lifespan comparisons
Double mutant LPL-4(OE);pha-4(RNAi) has a lifespan of 18.9 days, while single mutant pha-4(RNAi) has a lifespan of 18.2 days, single mutant LPL-4(OE) has a lifespan of 23.5 days and wild type has a lifespan of 19.0 days.
Type of interaction
See methods
Opposite lifespan effects of single mutants
Citation
View abstract
Lapierre LR et al., 2011, Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans. Curr Biol. 21(18):1507-14 21906946 Click here to select all mutants from this PubMed ID in the graph
Abstract
The cellular recycling process of autophagy is emerging as a key player in several longevity pathways in Caenorhabditis elegans. Here, we identify a role for autophagy in long-lived animals lacking a germline and show that autophagy and lipid metabolism work interdependently to modulate aging in this longevity model.

Temperature °C
20
Diet
OP50; HT115E
Lifespan (days)
17.5
Lifespan change (compared to wild type)
-4.89%
Phenotype
RNAi-mediated inhibition of pha-4 significantly reduced the lifespan of LIPL-4 overexpressing animals, while having negligible effects on non-transgenic siblings.
Lifespan comparisons
Double mutant LPL-4(OE);pha-4(RNAi) has a lifespan of 17.5 days, while single mutant pha-4(RNAi) has a lifespan of 18.7 days, single mutant LPL-4(OE) has a lifespan of 22.7 days and wild type has a lifespan of 18.4 days.
Type of interaction
See methods
Antagonistic (negative)
Citation
View abstract
Lapierre LR et al., 2011, Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans. Curr Biol. 21(18):1507-14 21906946 Click here to select all mutants from this PubMed ID in the graph
Abstract
The cellular recycling process of autophagy is emerging as a key player in several longevity pathways in Caenorhabditis elegans. Here, we identify a role for autophagy in long-lived animals lacking a germline and show that autophagy and lipid metabolism work interdependently to modulate aging in this longevity model.

Temperature °C
20
Diet
OP50; HT115E
Lifespan (days)
16.4
Lifespan change (compared to wild type)
-11.35%
Phenotype
RNAi-mediated inhibition of pha-4 significantly reduced the lifespan of LIPL-4 overexpressing animals, while having negligible effects on non-transgenic siblings.
Lifespan comparisons
Double mutant LPL-4(OE);pha-4(RNAi) has a lifespan of 16.4 days, while single mutant pha-4(RNAi) has a lifespan of 17.4 days, single mutant LPL-4(OE) has a lifespan of 21.4 days and wild type has a lifespan of 18.5 days.
Type of interaction
See methods
Opposite lifespan effects of single mutants
Citation
View abstract
Lapierre LR et al., 2011, Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans. Curr Biol. 21(18):1507-14 21906946 Click here to select all mutants from this PubMed ID in the graph
Abstract
The cellular recycling process of autophagy is emerging as a key player in several longevity pathways in Caenorhabditis elegans. Here, we identify a role for autophagy in long-lived animals lacking a germline and show that autophagy and lipid metabolism work interdependently to modulate aging in this longevity model.

Search genes: LPL-4 pha-4

Symbol
GenAge

LPL-4
View on GenAge (LPL-4)

No gene information for LPL-4

Entrez ID
Symbol
GenAge
Wormbase ID

180357
pha-4
View on GenAge (pha-4)
WBGene00004013

Defective pharyngeal development protein 4

Locus: CELE_F38A6.1

Wormbase description: pha-4 encodes a FoxA transcription factor; during embryonic development, PHA-4 functions as an organ identity gene whose activity is necessary and sufficient for development of the pharynx/foregut; in addition, PHA-4 plays a key role in regulation of diet-restriction-induced longevity in adult animals; PHA-4 expression begins early in embryogenesis and is seen in pharyngeal and intestinal cells (foregut and midgut); PHA-4 is also expressed later in the developing somatic gonad.

Orthologs of LPL-4;pha-4 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene

Orthologs of LPL-4 in SynergyAge

Show in SynergyAge
Species	Gene

Orthologs of pha-4 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	FoxK