LPL-4;vps-34

There is no network for this step.

Fullscreen mode

Hide graph

Legend

Genetic mutants with LPL-4, vps-34 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Diet
OP50; HT115E
Lifespan (days)
17.5
Lifespan change (compared to wild type)
-7.89%
Phenotype
RNAi-mediated inhibition of vps-34 significantly reduced the lifespan of LIPL-4 overexpressing animals, while having negligible effects on non-transgenic siblings.
Lifespan comparisons
Double mutant LPL-4(OE);vps-34(RNAi) has a lifespan of 17.5 days, while single mutant vps-34(RNAi) has a lifespan of 20.3 days, single mutant LPL-4(OE) has a lifespan of 23.5 days and wild type has a lifespan of 19.0 days.
Type of interaction
See methods
Antagonistic (negative)
Citation
View abstract
Lapierre LR et al., 2011, Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans. Curr Biol. 21(18):1507-14 21906946 Click here to select all mutants from this PubMed ID in the graph
Abstract
The cellular recycling process of autophagy is emerging as a key player in several longevity pathways in Caenorhabditis elegans. Here, we identify a role for autophagy in long-lived animals lacking a germline and show that autophagy and lipid metabolism work interdependently to modulate aging in this longevity model.

Temperature °C
20
Diet
OP50; HT115E
Lifespan (days)
20.7
Lifespan change (compared to wild type)
7.81%
Phenotype
RNAi-mediated inhibition of vps-34 significantly reduced the lifespan of LIPL-4 overexpressing animals, while having negligible effects on non-transgenic siblings.
Lifespan comparisons
Double mutant LPL-4(OE);vps-34(RNAi) has a lifespan of 20.7 days, while single mutant vps-34(RNAi) has a lifespan of 19.0 days, single mutant LPL-4(OE) has a lifespan of 24.0 days and wild type has a lifespan of 19.2 days.
Type of interaction
See methods
Opposite lifespan effects of single mutants
Citation
View abstract
Lapierre LR et al., 2011, Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans. Curr Biol. 21(18):1507-14 21906946 Click here to select all mutants from this PubMed ID in the graph
Abstract
The cellular recycling process of autophagy is emerging as a key player in several longevity pathways in Caenorhabditis elegans. Here, we identify a role for autophagy in long-lived animals lacking a germline and show that autophagy and lipid metabolism work interdependently to modulate aging in this longevity model.

Temperature °C
20
Diet
OP50; HT115E
Lifespan (days)
16.7
Lifespan change (compared to wild type)
-9.24%
Phenotype
RNAi-mediated inhibition of vps-34 significantly reduced the lifespan of LIPL-4 overexpressing animals, while having negligible effects on non-transgenic siblings.
Lifespan comparisons
Double mutant LPL-4(OE);vps-34(RNAi) has a lifespan of 16.7 days, while single mutant vps-34(RNAi) has a lifespan of 19.6 days, single mutant LPL-4(OE) has a lifespan of 22.7 days and wild type has a lifespan of 18.4 days.
Type of interaction
See methods
Antagonistic (negative)
Citation
View abstract
Lapierre LR et al., 2011, Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans. Curr Biol. 21(18):1507-14 21906946 Click here to select all mutants from this PubMed ID in the graph
Abstract
The cellular recycling process of autophagy is emerging as a key player in several longevity pathways in Caenorhabditis elegans. Here, we identify a role for autophagy in long-lived animals lacking a germline and show that autophagy and lipid metabolism work interdependently to modulate aging in this longevity model.

Search genes: LPL-4 vps-34

Symbol
GenAge

LPL-4
View on GenAge (LPL-4)

No gene information for LPL-4

Entrez ID
Symbol
GenAge
Wormbase ID

172280
vps-34
View on GenAge (vps-34)
WBGene00006932

Phosphatidylinositol 3-kinase catalytic subunit type 3

Locus: CELE_B0025.1

Wormbase description: vps-34 encodes an ortholog of the phosphoinositide 3-kinase VPS34 in S. cerevisiae, a protein that regulates multiple steps in endocytosis, and that is required for growth at normal rates during development; in C. elegans, vps-34 is required for vesicular trafficking, including endocytosis, apoptotic cell clearance, and autophagy.

Orthologs of LPL-4;vps-34 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene

Orthologs of LPL-4 in SynergyAge

Show in SynergyAge
Species	Gene

Orthologs of vps-34 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	Pi3K59F
Mus musculus	Pik3c3