LPL-4;tor

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Genetic mutants with LPL-4, tor alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Diet
OP50; HT115E
Lifespan (days)
24.9
Lifespan change (compared to wild type)
31.05%
Lifespan comparisons
Double mutant LPL-4(OE);tor(RNAi) has a lifespan of 24.9 days, while single mutant tor(RNAi) has a lifespan of 22.7 days, single mutant LPL-4(OE) has a lifespan of 23.5 days and wild type has a lifespan of 19.0 days.
Type of interaction
See methods
Almost additive (positive)
Citation
View abstract
Lapierre LR et al., 2011, Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans. Curr Biol. 21(18):1507-14 21906946 Click here to select all mutants from this PubMed ID in the graph
Abstract
The cellular recycling process of autophagy is emerging as a key player in several longevity pathways in Caenorhabditis elegans. Here, we identify a role for autophagy in long-lived animals lacking a germline and show that autophagy and lipid metabolism work interdependently to modulate aging in this longevity model.

Temperature °C
20
Diet
OP50; HT115E
Lifespan (days)
24.0
Lifespan change (compared to wild type)
30.43%
Lifespan comparisons
Double mutant LPL-4(OE);tor(RNAi) has a lifespan of 24.0 days, while single mutant tor(RNAi) has a lifespan of 23.1 days, single mutant LPL-4(OE) has a lifespan of 22.7 days and wild type has a lifespan of 18.4 days.
Type of interaction
See methods
Almost additive (positive)
Citation
View abstract
Lapierre LR et al., 2011, Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans. Curr Biol. 21(18):1507-14 21906946 Click here to select all mutants from this PubMed ID in the graph
Abstract
The cellular recycling process of autophagy is emerging as a key player in several longevity pathways in Caenorhabditis elegans. Here, we identify a role for autophagy in long-lived animals lacking a germline and show that autophagy and lipid metabolism work interdependently to modulate aging in this longevity model.

Temperature °C
20
Diet
OP50; HT115E
Lifespan (days)
21.5
Lifespan change (compared to wild type)
16.22%
Lifespan comparisons
Double mutant LPL-4(OE);tor(RNAi) has a lifespan of 21.5 days, while single mutant tor(RNAi) has a lifespan of 21.3 days, single mutant LPL-4(OE) has a lifespan of 21.4 days and wild type has a lifespan of 18.5 days.
Type of interaction
See methods
Almost additive (positive)
Citation
View abstract
Lapierre LR et al., 2011, Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans. Curr Biol. 21(18):1507-14 21906946 Click here to select all mutants from this PubMed ID in the graph
Abstract
The cellular recycling process of autophagy is emerging as a key player in several longevity pathways in Caenorhabditis elegans. Here, we identify a role for autophagy in long-lived animals lacking a germline and show that autophagy and lipid metabolism work interdependently to modulate aging in this longevity model.

Search genes: LPL-4 tor

Symbol
GenAge

LPL-4
View on GenAge (LPL-4)

No gene information for LPL-4

Symbol
GenAge

tor
View on GenAge (tor)

No gene information for tor

Orthologs of LPL-4;tor in SynergyAge

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Orthologs of LPL-4 in SynergyAge

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Orthologs of tor in SynergyAge

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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.