rps-15;rsks-1

Lifespan changes: From wild type to rps-15;rsks-1

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Genetic mutants with rps-15, rsks-1 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    20

  • Lifespan (days)

    26.4

  • Phenotype

    The lifespans of S6K/rsks-1(sv31) and eIF4E/ife-2(ok306) mutants subjected to TOR RNAi were longer than the lifespans of either the S6K or eIF4E mutant alone

  • Lifespan comparisons

    Double mutant rps-15(RNAi);rsks-1(sv31) has a lifespan of 26.4 days, while single mutant rsks-1(sv31) has a lifespan of 21.8 days.

  • Citation
    View abstract

    Hansen M et al., 2007, Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell. 6(1):95-110 PubMed 17266679 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    20

  • Lifespan (days)

    20.4

  • Phenotype

    The lifespans of S6K/rsks-1(sv31) and eIF4E/ife-2(ok306) mutants subjected to TOR RNAi were longer than the lifespans of either the S6K or eIF4E mutant alone

  • Lifespan comparisons

    Double mutant rps-15(RNAi);rsks-1(sv31) has a lifespan of 20.4 days, while single mutant rsks-1(sv31) has a lifespan of 20.2 days.

  • Citation
    View abstract

    Hansen M et al., 2007, Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell. 6(1):95-110 PubMed 17266679 Click here to select all mutants from this PubMed ID in the graph

Search genes: rps-15 rsks-1
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

40S ribosomal protein S15


Locus: CELE_F36A2.6


Wormbase description: rps-15 encodes a small ribosomal subunit S15 protein.


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Ribosomal protein S6 kinase beta


Locus: CELE_Y47D3A.16


Wormbase description: rsks-1 encodes a putative ribosomal protein S6 kinase (S6K) required additively with IFG-1 for normally high levels of protein synthesis, and for normally short lifespan; RSKS-1's effect on lifespan is independent of DAF-16, ISP-1, and SIR-2.1, and does not correlate with juglone resistance, but does correlate with abnormally high resistance to starvation and (perhaps) thermotolerance; RSKS-1 is required for normal juglone resistance, as well as normally rapid growth and normal brood sizes; RSKS-1 is expressed in E-lineage embryonic cells, and in pharyngeal and hypodermal cells of larvae and adults; RSKS-1 is orthologous to human RPS6KB1 (OMIM:608938) and RPS6KB2 (OMIM:608939).


Orthologs of rps-15;rsks-1 in SynergyAge
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Orthologs of rps-15 in SynergyAge
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Orthologs of rsks-1 in SynergyAge
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About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Contact
Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania
Email:

Group webpage: www.aging-research.group