daf-10;nmur-1

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Genetic mutants with daf-10, nmur-1 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
25
Diet
OP50
Lifespan (days)
21.1
Lifespan change (compared to wild type)
86.73%
Phenotype
Loss of nmur-1 still considerably increases the lifespan of daf-10 sensory mutants on OP50, which indicates that nmur-1 acts in parallel at least to some daf-10-expressing neurons. Surprisingly, loss of nmur-1 extends the lifespan of daf-10 mutants also on HT115, which may suggest that the lifespan of nmur-1 mutants becomes food source independent in the absence of daf-10 activity.
Lifespan comparisons
Double mutant daf-10(m79);nmur-1(ok1387) has a lifespan of 21.1 days, while single mutant nmur-1(ok1387) has a lifespan of 15.4 days, single mutant daf-10(m79) has a lifespan of 16.3 days and wild type has a lifespan of 11.3 days.
Type of interaction
See methods
Synergistic (positive)
Citation
View abstract
Maier W et al., 2010, A neuromedin U receptor acts with the sensory system to modulate food type-dependent effects on C. elegans lifespan. PLoS Biol. 8(5):e1000376 20520844 Click here to select all mutants from this PubMed ID in the graph
Abstract
The type of food source has previously been shown to be as important as the level of food intake in influencing lifespan. Here we report that different Escherichia coli food sources alter Caenorhabditis elegans lifespan. These effects are modulated by different subsets of sensory neurons, which act with nmur-1, a homolog of mammalian neuromedin U receptors. Wild-type nmur-1, which is expressed in the somatic gonad, sensory neurons, and interneurons, shortens lifespan only on specific E. coli food sources-an effect that is dependent on the type of E. coli lipopolysaccharide structure. Moreover, the food type-dependent effect of nmur-1 on lifespan is different from that of food-level restriction. Together our data suggest that nmur-1 processes information from specific food cues to influence lifespan and other aspects of physiology.

Temperature °C
25
Diet
HT115
Lifespan (days)
21.8
Lifespan change (compared to wild type)
80.17%
Phenotype
Loss of nmur-1 still considerably increases the lifespan of daf-10 sensory mutants on OP50, which indicates that nmur-1 acts in parallel at least to some daf-10-expressing neurons. Surprisingly, loss of nmur-1 extends the lifespan of daf-10 mutants also on HT115, which may suggest that the lifespan of nmur-1 mutants becomes food source independent in the absence of daf-10 activity.
Lifespan comparisons
Double mutant daf-10(m79);nmur-1(ok1387) has a lifespan of 21.8 days, while single mutant nmur-1(ok1387) has a lifespan of 12.2 days, single mutant daf-10(m79) has a lifespan of 17.7 days and wild type has a lifespan of 12.1 days.
Type of interaction
See methods
Synergistic (positive)
Citation
View abstract
Maier W et al., 2010, A neuromedin U receptor acts with the sensory system to modulate food type-dependent effects on C. elegans lifespan. PLoS Biol. 8(5):e1000376 20520844 Click here to select all mutants from this PubMed ID in the graph
Abstract
The type of food source has previously been shown to be as important as the level of food intake in influencing lifespan. Here we report that different Escherichia coli food sources alter Caenorhabditis elegans lifespan. These effects are modulated by different subsets of sensory neurons, which act with nmur-1, a homolog of mammalian neuromedin U receptors. Wild-type nmur-1, which is expressed in the somatic gonad, sensory neurons, and interneurons, shortens lifespan only on specific E. coli food sources-an effect that is dependent on the type of E. coli lipopolysaccharide structure. Moreover, the food type-dependent effect of nmur-1 on lifespan is different from that of food-level restriction. Together our data suggest that nmur-1 processes information from specific food cues to influence lifespan and other aspects of physiology.

Search genes: daf-10 nmur-1

Entrez ID
Symbol
GenAge
Wormbase ID

184883
daf-10
View on GenAge (daf-10)
WBGene00000906

Intraflagellar transport protein 122 homolog

Locus: CELE_F23B2.4

Wormbase description: daf-10 encodes a WD- and WAA-repeat containing protein that is the C. elegans ortholog of intraflagellar transport (IFT) complex A component IFT122; daf-10 activity is required for intraflagellar transport and thus for proper development of amphid and phasmid neurons, dauer development, chemotaxis, and normal lifespan; a DAF-10::GFP fusion protein undergoes both anterograde and retrograde intraflagellar transport in amphid or phasmid sensory neurons.

Entrez ID
Symbol
GenAge
Wormbase ID

183574
nmur-1
View on GenAge (nmur-1)
WBGene00016747

NMUR (NeuroMedin U Receptor) homolog

Locus: CELE_C48C5.1

Wormbase description: none available

Orthologs of daf-10;nmur-1 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene

Orthologs of daf-10 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	Oseg1
Mus musculus	Ift122

Orthologs of nmur-1 in SynergyAge

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Species	Gene