nmur-1;osm-3

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Genetic mutants with nmur-1, osm-3 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
25
Diet
OP50
Lifespan (days)
15.2
Lifespan change (compared to wild type)
44.76%
Phenotype
Animals that carry both nmur-1 and osm-3 mutations have a lifespan phenotype similar to that of nmur-1 single mutants on OP50 and HT115. This suggests that nmur-1 acts with osm-3 either in a subset of osm-3-expressing sensory neurons or in downstream cells.
Lifespan comparisons
Double mutant nmur-1(ok1387);osm-3(n1540) has a lifespan of 15.2 days, while single mutant nmur-1(ok1387) has a lifespan of 14.0 days, single mutant osm-3(n1540) has a lifespan of 12.9 days and wild type has a lifespan of 10.5 days.
Type of interaction
See methods
Almost additive (positive)
Citation
View abstract
Maier W et al., 2010, A neuromedin U receptor acts with the sensory system to modulate food type-dependent effects on C. elegans lifespan. PLoS Biol. 8(5):e1000376 20520844 Click here to select all mutants from this PubMed ID in the graph
Abstract
The type of food source has previously been shown to be as important as the level of food intake in influencing lifespan. Here we report that different Escherichia coli food sources alter Caenorhabditis elegans lifespan. These effects are modulated by different subsets of sensory neurons, which act with nmur-1, a homolog of mammalian neuromedin U receptors. Wild-type nmur-1, which is expressed in the somatic gonad, sensory neurons, and interneurons, shortens lifespan only on specific E. coli food sources-an effect that is dependent on the type of E. coli lipopolysaccharide structure. Moreover, the food type-dependent effect of nmur-1 on lifespan is different from that of food-level restriction. Together our data suggest that nmur-1 processes information from specific food cues to influence lifespan and other aspects of physiology.

Temperature °C
25
Diet
HT115
Lifespan (days)
13.8
Lifespan change (compared to wild type)
16.95%
Phenotype
Animals that carry both nmur-1 and osm-3 mutations have a lifespan phenotype similar to that of nmur-1 single mutants on OP50 and HT115. This suggests that nmur-1 acts with osm-3 either in a subset of osm-3-expressing sensory neurons or in downstream cells.
Lifespan comparisons
Double mutant nmur-1(ok1387);osm-3(n1540) has a lifespan of 13.8 days, while single mutant nmur-1(ok1387) has a lifespan of 12.7 days, single mutant osm-3(n1540) has a lifespan of 12.6 days and wild type has a lifespan of 11.8 days.
Type of interaction
See methods
Synergistic (positive)
Citation
View abstract
Maier W et al., 2010, A neuromedin U receptor acts with the sensory system to modulate food type-dependent effects on C. elegans lifespan. PLoS Biol. 8(5):e1000376 20520844 Click here to select all mutants from this PubMed ID in the graph
Abstract
The type of food source has previously been shown to be as important as the level of food intake in influencing lifespan. Here we report that different Escherichia coli food sources alter Caenorhabditis elegans lifespan. These effects are modulated by different subsets of sensory neurons, which act with nmur-1, a homolog of mammalian neuromedin U receptors. Wild-type nmur-1, which is expressed in the somatic gonad, sensory neurons, and interneurons, shortens lifespan only on specific E. coli food sources-an effect that is dependent on the type of E. coli lipopolysaccharide structure. Moreover, the food type-dependent effect of nmur-1 on lifespan is different from that of food-level restriction. Together our data suggest that nmur-1 processes information from specific food cues to influence lifespan and other aspects of physiology.

Temperature °C
25
Diet
CS180
Lifespan (days)
15.7
Lifespan change (compared to wild type)
13.77%
Phenotype
Animals that carry both nmur-1 and osm-3 mutations have a lifespan phenotype similar to that of nmur-1 single mutants on OP50 and HT115. This suggests that nmur-1 acts with osm-3 either in a subset of osm-3-expressing sensory neurons or in downstream cells.
Lifespan comparisons
Double mutant nmur-1(ok1387);osm-3(n1540) has a lifespan of 15.7 days, while single mutant nmur-1(ok1387) has a lifespan of 14.4 days, single mutant osm-3(n1540) has a lifespan of 15.5 days and wild type has a lifespan of 13.8 days.
Type of interaction
See methods
Almost additive (positive)
Citation
View abstract
Maier W et al., 2010, A neuromedin U receptor acts with the sensory system to modulate food type-dependent effects on C. elegans lifespan. PLoS Biol. 8(5):e1000376 20520844 Click here to select all mutants from this PubMed ID in the graph
Abstract
The type of food source has previously been shown to be as important as the level of food intake in influencing lifespan. Here we report that different Escherichia coli food sources alter Caenorhabditis elegans lifespan. These effects are modulated by different subsets of sensory neurons, which act with nmur-1, a homolog of mammalian neuromedin U receptors. Wild-type nmur-1, which is expressed in the somatic gonad, sensory neurons, and interneurons, shortens lifespan only on specific E. coli food sources-an effect that is dependent on the type of E. coli lipopolysaccharide structure. Moreover, the food type-dependent effect of nmur-1 on lifespan is different from that of food-level restriction. Together our data suggest that nmur-1 processes information from specific food cues to influence lifespan and other aspects of physiology.

Temperature °C
25
Diet
CS2429
Lifespan (days)
14.8
Lifespan change (compared to wild type)
15.63%
Phenotype
Animals that carry both nmur-1 and osm-3 mutations have a lifespan phenotype similar to that of nmur-1 single mutants on OP50 and HT115. This suggests that nmur-1 acts with osm-3 either in a subset of osm-3-expressing sensory neurons or in downstream cells.
Lifespan comparisons
Double mutant nmur-1(ok1387);osm-3(n1540) has a lifespan of 14.8 days, while single mutant nmur-1(ok1387) has a lifespan of 14.2 days, single mutant osm-3(n1540) has a lifespan of 15.3 days and wild type has a lifespan of 12.8 days.
Type of interaction
See methods
Dependent
Citation
View abstract
Maier W et al., 2010, A neuromedin U receptor acts with the sensory system to modulate food type-dependent effects on C. elegans lifespan. PLoS Biol. 8(5):e1000376 20520844 Click here to select all mutants from this PubMed ID in the graph
Abstract
The type of food source has previously been shown to be as important as the level of food intake in influencing lifespan. Here we report that different Escherichia coli food sources alter Caenorhabditis elegans lifespan. These effects are modulated by different subsets of sensory neurons, which act with nmur-1, a homolog of mammalian neuromedin U receptors. Wild-type nmur-1, which is expressed in the somatic gonad, sensory neurons, and interneurons, shortens lifespan only on specific E. coli food sources-an effect that is dependent on the type of E. coli lipopolysaccharide structure. Moreover, the food type-dependent effect of nmur-1 on lifespan is different from that of food-level restriction. Together our data suggest that nmur-1 processes information from specific food cues to influence lifespan and other aspects of physiology.

Search genes: nmur-1 osm-3

Entrez ID
Symbol
GenAge
Wormbase ID

183574
nmur-1
View on GenAge (nmur-1)
WBGene00016747

NMUR (NeuroMedin U Receptor) homolog

Locus: CELE_C48C5.1

Wormbase description: none available

Entrez ID
Symbol
GenAge
Wormbase ID

177141
osm-3
View on GenAge (osm-3)
WBGene00003884

Osmotic avoidance abnormal protein 3

Locus: CELE_M02B7.3

Wormbase description: osm-3 encodes a kinesin-2 family member that forms a homodimeric kinesin motor protein; OSM-3, in conjunction with the heterotrimeric kinesin-II composed of KLP-20, KLP-11, and KAP-1, is required for intraflagellar transport (IFT) along the middle segment of the cilia and on its own, is required for IFT along the distal segment; OSM-3 is thus also required for formation of the distal segment of amphid channel cilia, responses to osmotic stimuli, dauer formation, and sensitivity to caffeine; OSM-3 is intensely localized in the ciliated endings of amphid, inner labial, and phasmid chemosensory neurons and shows a punctate localization pattern in the corresponding cell bodies and dendrites.

Orthologs of nmur-1;osm-3 in SynergyAge

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Species	Gene

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Species	Gene

Orthologs of nmur-1 in SynergyAge

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Species	Gene

Orthologs of osm-3 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	Kif3C