aak-2;nmur-1

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Genetic mutants with aak-2, nmur-1 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
25
Diet
OP50
Lifespan (days)
13.8
Lifespan change (compared to wild type)
23.21%
Phenotype
We found that loss of nmur-1 can still extend the lifespan of animals with a mutation in the AMP-dependent kinase aak-2, which regulatesenergy metabolism.
Lifespan comparisons
Double mutant aak-2(ok524);nmur-1(ok1387) has a lifespan of 13.8 days, while single mutant nmur-1(ok1387) has a lifespan of 14.8 days, single mutant aak-2(ok524) has a lifespan of 10.8 days and wild type has a lifespan of 11.2 days.
Type of interaction
See methods
Opposite lifespan effects of single mutants
Citation
View abstract
Maier W et al., 2010, A neuromedin U receptor acts with the sensory system to modulate food type-dependent effects on C. elegans lifespan. PLoS Biol. 8(5):e1000376 20520844 Click here to select all mutants from this PubMed ID in the graph
Abstract
The type of food source has previously been shown to be as important as the level of food intake in influencing lifespan. Here we report that different Escherichia coli food sources alter Caenorhabditis elegans lifespan. These effects are modulated by different subsets of sensory neurons, which act with nmur-1, a homolog of mammalian neuromedin U receptors. Wild-type nmur-1, which is expressed in the somatic gonad, sensory neurons, and interneurons, shortens lifespan only on specific E. coli food sources-an effect that is dependent on the type of E. coli lipopolysaccharide structure. Moreover, the food type-dependent effect of nmur-1 on lifespan is different from that of food-level restriction. Together our data suggest that nmur-1 processes information from specific food cues to influence lifespan and other aspects of physiology.

Search genes: aak-2 nmur-1

Entrez ID
Symbol
GenAge
Wormbase ID

181727
aak-2
View on GenAge (aak-2)
WBGene00020142

5'-AMP-activated protein kinase catalytic subunit alpha-2

Locus: CELE_T01C8.1

Wormbase description: aak-2 encodes one of two C. elegans homologs of the catalytic alpha subunit of AMP-activated protein kinases (AMPKs); in C. elegans, aak-2 functions downstream of environmental stressors, energy level signals (AMP:ATP ratio), and daf-2-mediated insulin signaling to positively regulate adult lifespan; in regulating lifespan, aak-2 likely acts in parallel with daf-16/FOXO; aak-2 activity is also required for dauer formation in daf-2 mutant animals at high temperature in a manner independent of the AMP:ATP ratio; in the germline, aak-2 functions downstream of daf-2 and daf-7, and in parallel to par-4 and aak-1, to negatively regulate germline proliferation during dauer development; in vitro, AAK-2 exhibits AMP-enhanced kinase activity against a known AMPK substrate, the SAMS peptide.

Entrez ID
Symbol
GenAge
Wormbase ID

183574
nmur-1
View on GenAge (nmur-1)
WBGene00016747

NMUR (NeuroMedin U Receptor) homolog

Locus: CELE_C48C5.1

Wormbase description: none available

Orthologs of aak-2;nmur-1 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene

Orthologs of aak-2 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	AMPKalpha
Mus musculus	Prkaa1
Mus musculus	Prkaa2

Orthologs of nmur-1 in SynergyAge

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Species	Gene

About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.