flr-4;pmk-3

Lifespan changes: From wild type to flr-4;pmk-3

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Genetic mutants with flr-4, pmk-3 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    20

  • Diet

    OP50; HT121

  • Lifespan (days)

    26.24

  • Lifespan change (compared to wild type)

    51.94%

  • Lifespan comparisons

    Double mutant flr-4(RNAi);pmk-3(ok169) has a lifespan of 26.24 days, while single mutant pmk-3(ok169) has a lifespan of 16.52 days and wild type has a lifespan of 17.27 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Verma S et al., 2018, A novel gene-diet pair modulates C. elegans aging. PLoS Genet. 14(8):e1007608 PubMed 30125273 Click here to select all mutants from this PubMed ID in the graph

Search genes: flr-4 pmk-3
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Serine/threonine-protein kinase flr-4


Locus: CELE_F09B12.6


Wormbase description: flr-4 encodes a predicted Ser/Thr protein kinase that affects sensitivity to fluoride ion, growth, defecation cycle periods, dauer formation; expressed in the intestine, the AUA neurons, the pharyngeal isthmus, and in the excretory canal in larval stages.


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Mitogen-activated protein kinase pmk-3;P38 Map Kinase family


Locus: CELE_F42G8.4


Wormbase description: pmk-3 encodes a homolog of p38, a mitogen-activated protein kinase (MAPK), activated in vitro by MEK6, indicating that it does respond like p38 to physiological stress; PMK-3 is expressed in nuclei throughout the intestine; PMK-3 is activated by osmotic stresses when heterologously expressed in mammalian cells; null mutants do not exhibit observable growth defects or hypersensitivity to several tested known stresses.


Orthologs of flr-4;pmk-3 in SynergyAge
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Orthologs of flr-4 in SynergyAge
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Orthologs of pmk-3 in SynergyAge
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About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Contact
Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania
Email:

Group webpage: www.aging-research.group