Lifespan changes: From wild type to flr-4;pmk-3
20
OP50; HT121
26.24
51.94%
Double mutant flr-4(RNAi);pmk-3(ok169) has a lifespan of 26.24 days, while single mutant pmk-3(ok169) has a lifespan of 16.52 days and wild type has a lifespan of 17.27 days.
Opposite lifespan effects of single mutants
Verma S et al., 2018, A novel gene-diet pair modulates C. elegans aging. PLoS Genet. 14(8):e1007608 30125273 Click here to select all mutants from this PubMed ID in the graph
Serine/threonine-protein kinase flr-4
Locus: CELE_F09B12.6
Wormbase description: flr-4 encodes a predicted Ser/Thr protein kinase that affects sensitivity to fluoride ion, growth, defecation cycle periods, dauer formation; expressed in the intestine, the AUA neurons, the pharyngeal isthmus, and in the excretory canal in larval stages.
Mitogen-activated protein kinase pmk-3;P38 Map Kinase family
Locus: CELE_F42G8.4
Wormbase description: pmk-3 encodes a homolog of p38, a mitogen-activated protein kinase (MAPK), activated in vitro by MEK6, indicating that it does respond like p38 to physiological stress; PMK-3 is expressed in nuclei throughout the intestine; PMK-3 is activated by osmotic stresses when heterologously expressed in mammalian cells; null mutants do not exhibit observable growth defects or hypersensitivity to several tested known stresses.
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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group