flr-4;sek-1

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Genetic mutants with flr-4, sek-1 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Diet
OP50; HT122
Lifespan (days)
18.45
Lifespan change (compared to wild type)
6.83%
Lifespan comparisons
Double mutant flr-4(RNAi);sek-1(km4) has a lifespan of 18.45 days, while single mutant sek-1(km4) has a lifespan of 17.74 days and wild type has a lifespan of 17.27 days.
Type of interaction
See methods
Dependent
Citation
View abstract
Verma S et al., 2018, A novel gene-diet pair modulates C. elegans aging. PLoS Genet. 14(8):e1007608 30125273 Click here to select all mutants from this PubMed ID in the graph
Abstract
Diet profoundly affects metabolism and incidences of age-related diseases. Animals adapt their physiology to different food-types, modulating complex life-history traits like aging. The molecular mechanisms linking adaptive capacity to diet with aging are less known. We identify FLR-4 kinase as a novel modulator of aging in C. elegans, depending on bacterial diet. FLR-4 functions to prevent differential activation of the p38MAPK pathway in response to diverse food-types, thereby maintaining normal life span. In a kinase-dead flr-4 mutant, E. coli HT115 (K12 strain), but not the standard diet OP50 (B strain), is able to activate p38MAPK, elevate expression of cytoprotective genes through the nuclear hormone receptor NHR-8 and enhance life span. Interestingly, flr-4 and dietary restriction utilize similar pathways for longevity assurance, suggesting cross-talks between cellular modules that respond to diet quality and quantity. Together, our study discovers a new C. elegans gene-diet pair that controls the plasticity of aging.

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Diet
OP50; HT125
Lifespan (days)
20.74
Lifespan change (compared to wild type)
-3.53%
Phenotype
The extended life span of flr-4(n2259) is suppressed by sek-1 RNAi.
Lifespan comparisons
Double mutant flr-4(n2259);sek-1(RNAi) has a lifespan of 20.74 days, while single mutant sek-1(RNAi) has a lifespan of 21.76 days, single mutant flr-4(n2259) has a lifespan of 30.16 days and wild type has a lifespan of 21.5 days.
Type of interaction
See methods
Antagonistic (negative)
Citation
View abstract
Verma S et al., 2018, A novel gene-diet pair modulates C. elegans aging. PLoS Genet. 14(8):e1007608 30125273 Click here to select all mutants from this PubMed ID in the graph
Abstract
Diet profoundly affects metabolism and incidences of age-related diseases. Animals adapt their physiology to different food-types, modulating complex life-history traits like aging. The molecular mechanisms linking adaptive capacity to diet with aging are less known. We identify FLR-4 kinase as a novel modulator of aging in C. elegans, depending on bacterial diet. FLR-4 functions to prevent differential activation of the p38MAPK pathway in response to diverse food-types, thereby maintaining normal life span. In a kinase-dead flr-4 mutant, E. coli HT115 (K12 strain), but not the standard diet OP50 (B strain), is able to activate p38MAPK, elevate expression of cytoprotective genes through the nuclear hormone receptor NHR-8 and enhance life span. Interestingly, flr-4 and dietary restriction utilize similar pathways for longevity assurance, suggesting cross-talks between cellular modules that respond to diet quality and quantity. Together, our study discovers a new C. elegans gene-diet pair that controls the plasticity of aging.

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Diet
OP50; HT126
Lifespan (days)
19.49
Phenotype
The life span of flr-4(n2259) is suppressed to the levels of sek-1(km4) in the double mutant flr-4(n2259).
Lifespan comparisons
Double mutant flr-4(n2259);sek-1(km4) has a lifespan of 19.49 days, while single mutant sek-1(km4) has a lifespan of 17.56 days and single mutant flr-4(n2259) has a lifespan of 26.84 days.
Citation
View abstract
Verma S et al., 2018, A novel gene-diet pair modulates C. elegans aging. PLoS Genet. 14(8):e1007608 30125273 Click here to select all mutants from this PubMed ID in the graph
Abstract
Diet profoundly affects metabolism and incidences of age-related diseases. Animals adapt their physiology to different food-types, modulating complex life-history traits like aging. The molecular mechanisms linking adaptive capacity to diet with aging are less known. We identify FLR-4 kinase as a novel modulator of aging in C. elegans, depending on bacterial diet. FLR-4 functions to prevent differential activation of the p38MAPK pathway in response to diverse food-types, thereby maintaining normal life span. In a kinase-dead flr-4 mutant, E. coli HT115 (K12 strain), but not the standard diet OP50 (B strain), is able to activate p38MAPK, elevate expression of cytoprotective genes through the nuclear hormone receptor NHR-8 and enhance life span. Interestingly, flr-4 and dietary restriction utilize similar pathways for longevity assurance, suggesting cross-talks between cellular modules that respond to diet quality and quantity. Together, our study discovers a new C. elegans gene-diet pair that controls the plasticity of aging.

Search genes: flr-4 sek-1

Entrez ID
Symbol
GenAge
Wormbase ID

181604
flr-4
View on GenAge (flr-4)
WBGene00001468

Serine/threonine-protein kinase flr-4

Locus: CELE_F09B12.6

Wormbase description: flr-4 encodes a predicted Ser/Thr protein kinase that affects sensitivity to fluoride ion, growth, defecation cycle periods, dauer formation; expressed in the intestine, the AUA neurons, the pharyngeal isthmus, and in the excretory canal in larval stages.

Entrez ID
Symbol
GenAge
Wormbase ID

181043
sek-1
View on GenAge (sek-1)
WBGene00004758

Dual specificity mitogen-activated protein kinase kinase sek-1

Locus: CELE_R03G5.2

Wormbase description: SEK-1 encodes a MAPKK (Mitogen-Activated Protein Kinase Kinase); SEK-1 functions in the p38 MAPK cascade that regulates innate immunity; SEK-1 has MAPKK activity; SEK-1 can activate both JNK-1 and PMK-1 in the yeast Hog pathway.

Orthologs of flr-4;sek-1 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene

Orthologs of flr-4 in SynergyAge

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Species	Gene

Orthologs of sek-1 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	lic
Mus musculus	Map2k3
Mus musculus	Map2k6