flr-4;gld-1

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Genetic mutants with flr-4, gld-1 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Diet
OP50; HT138
Lifespan (days)
15.25
Lifespan change (compared to wild type)
17.31%
Lifespan comparisons
Double mutant flr-4(RNAi);gld-1(op236) has a lifespan of 15.25 days, while single mutant flr-4(RNAi) has a lifespan of 16.07 days, single mutant gld-1(op236) has a lifespan of 15.7 days and wild type has a lifespan of 13.0 days.
Type of interaction
See methods
Antagonistic (positive)
Citation
View abstract
Verma S et al., 2018, A novel gene-diet pair modulates C. elegans aging. PLoS Genet. 14(8):e1007608 30125273 Click here to select all mutants from this PubMed ID in the graph
Abstract
Diet profoundly affects metabolism and incidences of age-related diseases. Animals adapt their physiology to different food-types, modulating complex life-history traits like aging. The molecular mechanisms linking adaptive capacity to diet with aging are less known. We identify FLR-4 kinase as a novel modulator of aging in C. elegans, depending on bacterial diet. FLR-4 functions to prevent differential activation of the p38MAPK pathway in response to diverse food-types, thereby maintaining normal life span. In a kinase-dead flr-4 mutant, E. coli HT115 (K12 strain), but not the standard diet OP50 (B strain), is able to activate p38MAPK, elevate expression of cytoprotective genes through the nuclear hormone receptor NHR-8 and enhance life span. Interestingly, flr-4 and dietary restriction utilize similar pathways for longevity assurance, suggesting cross-talks between cellular modules that respond to diet quality and quantity. Together, our study discovers a new C. elegans gene-diet pair that controls the plasticity of aging.

Search genes: flr-4 gld-1

Entrez ID
Symbol
GenAge
Wormbase ID

181604
flr-4
View on GenAge (flr-4)
WBGene00001468

Serine/threonine-protein kinase flr-4

Locus: CELE_F09B12.6

Wormbase description: flr-4 encodes a predicted Ser/Thr protein kinase that affects sensitivity to fluoride ion, growth, defecation cycle periods, dauer formation; expressed in the intestine, the AUA neurons, the pharyngeal isthmus, and in the excretory canal in larval stages.

Entrez ID
Symbol
GenAge
Wormbase ID

172532
gld-1
View on GenAge (gld-1)
WBGene00001595

Female germline-specific tumor suppressor gld-1

Locus: CELE_T23G11.3

Wormbase description: gld-1 encodes a protein containing a K homology (KH) RNA binding domain; GLD-1 is required for regulation of the mitosis/meiosis decision during germline development (promotion of meiotic entry) in parallel with gld-2, gld-3, and nos-3 and also affects spermatogenesis; GLD-1 physically interacts with the 3'- and 5'UTR of its putative mRNA targets in vitro to negatively regulate their translation; GLD-1 also physically interacts with FOG-2, an F-box protein that promotes spermatogenesis; GLD-1 is expressed in the germ cell cytoplasm at high levels during meiotic prophase; GLD-1 phosphorylation and levels in the distal, mitotic germline are negatively regulated by CYE-1/cyclin E, CDK-2, and the RNA-binding protein FBF-1.

Orthologs of flr-4;gld-1 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene

Orthologs of flr-4 in SynergyAge

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Species	Gene

Orthologs of gld-1 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	qkr58E-3
Drosophila melanogaster	nsr
Drosophila melanogaster	CG3927
Drosophila melanogaster	qkr58E-1
Drosophila melanogaster	CG4021

About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.