hsf-1;old-1

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Genetic mutants with hsf-1, old-1 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Diet
HT115; OP53
Lifespan (days)
16.8
Lifespan change (compared to wild type)
-27.59%
Phenotype
hsf-1(RNAi) also suppressed longevity associated with other components of the insulin-like signaling pathway including OLD overexpressing animals.
Lifespan comparisons
Double mutant hsf-1(RNAi);old-1(zls3000) has a lifespan of 16.8 days, while single mutant hsf-1(RNAi) has a lifespan of 17.9 days, single mutant old-1(zls3000) has a lifespan of 28.0 days and wild type has a lifespan of 23.2 days.
Type of interaction
See methods
Enhancer, opposite lifespan effects
Citation
View abstract
Morley JF, Morimoto RI, 2004, Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones. Mol Biol Cell. 15(2):657-64 14668486 Click here to select all mutants from this PubMed ID in the graph
Abstract
The correlation between longevity and stress resistance observed in long-lived mutant animals suggests that the ability to sense and respond to environmental challenges could be important for the regulation of life span. We therefore examined the role of heat shock factor (HSF-1), a master transcriptional regulator of stress-inducible gene expression and protein folding homeostasis, in the regulation of longevity. Down-regulation of hsf-1 by RNA interference suppressed longevity of mutants in an insulin-like signaling (ILS) pathway that functions in the nervous system of Caenorhabditis elegans to influence aging. hsf-1 was also required for temperature-induced dauer larvae formation in an ILS mutant. Using tissue-specific expression of wild-type or dominant negative HSF-1, we demonstrated that HSF-1 acts in multiple tissues to regulate longevity. Down-regulation of individual molecular chaperones, transcriptional targets of HSF-1, also decreased longevity of long-lived mutant but not wild-type animals. However, suppression by individual chaperones was to a lesser extent, suggesting an important role for networks of chaperones. The interaction of ILS with HSF-1 could represent an important molecular strategy to couple the regulation of longevity with an ancient genetic switch that governs the ability of cells to sense and respond to stress.

Search genes: hsf-1 old-1

Entrez ID
Symbol
GenAge
Wormbase ID

173078
hsf-1
View on GenAge (hsf-1)
WBGene00002004

Heat Shock Factor

Locus: CELE_Y53C10A.12

Wormbase description: hsf-1 encodes the C. elegans heat-shock transcription factor ortholog; HSF-1 functions as a transcriptional regulator of stress-induced gene expression whose activity is required for heat-shock and proteotoxicity response, larval development, innate immunity, and regulation of adult lifespan; HSF-1 binds bovine calmodulin in vitro in a calcium-dependent manner.

Entrez ID
Symbol
GenAge
Wormbase ID

191737
old-1
View on GenAge (old-1)
WBGene00003862

Tyrosine-protein kinase receptor old-1

Locus: CELE_C08H9.5

Wormbase description: old-1 encodes a receptor protein tyrosine kinase; old-1 plays a role in stress resistance and regulation of adult lifespan; Murakami and Johnson showed that old-1 mRNA levels are upregulated in response to stress and in daf-2 and age-1 mutant backgrounds and that overexpression of old-1 in wild-type animals results in extended lifespan and increased resistance to heat and UV irradiation; in contrast, Murphy et al., showed that old-1 expression is downregulated in daf-2 mutants and that old-1(RNAi) in an rrf-3 mutant background slightly extends lifespan; an OLD-1::GFP fusion protein is expressed in the anterior region of worms, in neuronal, hypodermal, and pharyngeal tissues, as well as in the proximal region of the male gonad; expression is visible in young adults and appears to increase as animals age and in response to heat, starvation, or UV irradiation.

Orthologs of hsf-1;old-1 in SynergyAge

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Species	Gene

Orthologs of hsf-1 in SynergyAge

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Orthologs of old-1 in SynergyAge

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Species	Gene
Drosophila melanogaster	tor

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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.