rsks-1;sir-2.1

Lifespan changes: From wild type to rsks-1;sir-2.1

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Genetic mutants with rsks-1, sir-2.1 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    20

  • Diet

    NGM; OP50

  • Lifespan (days)

    20.2

  • Lifespan comparisons

    Double mutant rsks-1(RNAi);sir-2.1(ok424) has a lifespan of 20.2 days, while single mutant sir-2.1(ok424) has a lifespan of 15.2 days.

  • Citation
    View abstract

    Pan KZ et al., 2007, Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans. Aging Cell. 6(1):111-9 PubMed 17266680 Click here to select all mutants from this PubMed ID in the graph

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    20

  • Lifespan (days)

    20.0

  • Phenotype

     In each case, lifespan was extended. Thus, in C. elegans, SIR-2.1 is not required for the inhibition of translation, apparently by any mechanism, to increase lifespan.

  • Lifespan comparisons

    Double mutant rsks-1(RNAi);sir-2.1(ok434) has a lifespan of 20 days, while single mutant sir-2.1(ok434) has a lifespan of 16.9 days.

  • Citation
    View abstract

    Hansen M et al., 2007, Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell. 6(1):95-110 PubMed 17266679 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    20

  • Lifespan (days)

    19.8

  • Phenotype

     In each case, lifespan was extended. Thus, in C. elegans, SIR-2.1 is not required for the inhibition of translation, apparently by any mechanism, to increase lifespan.

  • Lifespan comparisons

    Double mutant rsks-1(RNAi);sir-2.1(ok434) has a lifespan of 19.8 days, while single mutant sir-2.1(ok434) has a lifespan of 17.5 days.

  • Citation
    View abstract

    Hansen M et al., 2007, Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell. 6(1):95-110 PubMed 17266679 Click here to select all mutants from this PubMed ID in the graph

Search genes: rsks-1 sir-2.1
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Ribosomal protein S6 kinase beta


Locus: CELE_Y47D3A.16


Wormbase description: rsks-1 encodes a putative ribosomal protein S6 kinase (S6K) required additively with IFG-1 for normally high levels of protein synthesis, and for normally short lifespan; RSKS-1's effect on lifespan is independent of DAF-16, ISP-1, and SIR-2.1, and does not correlate with juglone resistance, but does correlate with abnormally high resistance to starvation and (perhaps) thermotolerance; RSKS-1 is required for normal juglone resistance, as well as normally rapid growth and normal brood sizes; RSKS-1 is expressed in E-lineage embryonic cells, and in pharyngeal and hypodermal cells of larvae and adults; RSKS-1 is orthologous to human RPS6KB1 (OMIM:608938) and RPS6KB2 (OMIM:608939).


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

NAD-dependent protein deacetylase sir-2.1;yeast SIR related


Locus: CELE_R11A8.4


Wormbase description: sir-2.1 encodes an NAD-dependent protein deacetylase with similarity to Saccharomyces cerevisiae Sir2p and mammalian SIRT1.


Orthologs of rsks-1;sir-2.1 in SynergyAge
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Orthologs of rsks-1 in SynergyAge
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Orthologs of sir-2.1 in SynergyAge
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About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Contact
Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania
Email:

Group webpage: www.aging-research.group