oga-1;ogt-1

O-GlcNAc selective N-Acetyl-beta-D-glucosaminidase (O-GlcNAcase)

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Locus: CELE_T20B5.3

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Wormbase description: oga-1 encodes an ortholog of mammalian O-linked N-acetylglucosamine (O-GlcNAc)-selective N-acetyl-beta-D-glucosaminidase (O-GlcNAcase); a polymorphism of OGA-1's human ortholog MGEA5 is associated with type 2 diabetes, and OGA-1 appears to be required for fine-tuning of insulin signalling; oga-1(ok1207) mutants are viable and fertile but accumulate O-GlcNAc on nuclear pores and other proteins, while showing S/T-phosphorylation of proteins, increased GSK-3beta activity, excess glycogen and trehalose, and decreased lipid storage; oga-1(ok1207) mutations enhance the Daf-c phenotype of daf-2(e1370ts) alleles even under conditions where oga-1(ok1207) alone diminishes dauer formation.

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O-linked GlcNAc Transferase;UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase

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Locus: CELE_K04G7.3

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Wormbase description: ogt-1 encodes an ortholog of O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT; OMIM:300255) with 12 N-terminal tetratricopeptide (TPR) domains (generally thought to enable protein-protein interactions) and a C-terminal putative catalytic domain; although loss of ogt-1 activity has no effect on overall viability or fertility, ogt-1 mutations result in alterations in macronutrient storage and can suppress constitutive dauer formation in daf-2 mutants suggesting that, in C. elegans, ogt-1 may play a regulatory role in nutrient sensing and insulin-like signaling pathways; OGT-1 is expressed in embryos, where it exhibits nuclear and punctate perinuclear localization.

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