ocr-2;osm-9;tax-6

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Genetic mutants with ocr-2, osm-9, tax-6 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Diet
HT115
Lifespan (days)
23.45
Lifespan change (compared to wild type)
34.23%
Lifespan comparisons
Triple mutant ocr-2(ak47);osm-9(ky10);tax-6(RNAi) has a lifespan of 23.45 days, while single mutant tax-6(RNAi) has a lifespan of 26.0 days, double mutant ocr-2(ak47);osm-9(ky10) has a lifespan of 26.0 days and wild type has a lifespan of 17.47 days.
Citation
View abstract
Riera CE et al., 2014, TRPV1 pain receptors regulate longevity and metabolism by neuropeptide signaling. Cell. 157(5):1023-36 24855942 Click here to select all mutants from this PubMed ID in the graph
Abstract
The sensation of pain is associated with increased mortality, but it is unknown whether pain perception can directly affect aging. We find that mice lacking TRPV1 pain receptors are long-lived, displaying a youthful metabolic profile at old age. Loss of TRPV1 inactivates a calcium-signaling cascade that ends in the nuclear exclusion of the CREB-regulated transcriptional coactivator CRTC1 within pain sensory neurons originating from the spinal cord. In long-lived TRPV1 knockout mice, CRTC1 nuclear exclusion decreases production of the neuropeptide CGRP from sensory endings innervating the pancreatic islets, subsequently promoting insulin secretion and metabolic health. In contrast, CGRP homeostasis is disrupted with age in wild-type mice, resulting in metabolic decline. We show that pharmacologic inactivation of CGRP receptors in old wild-type animals can restore metabolic health. These data suggest that ablation of select pain sensory receptors or the inhibition of CGRP are associated with increased metabolic health and control longevity.

Search genes: ocr-2 osm-9 tax-6 ocr-2;osm-9;tax-6

Entrez ID
Symbol
GenAge
Wormbase ID

188314
ocr-2
View on GenAge (ocr-2)
WBGene00003839

Osm-9 and Capsaicin receptor-Related

Locus: CELE_T09A12.3

Wormbase description: ocr-2 encodes a TRPV (transient receptor potential channel, vanilloid subfamily) ion channel; OCR-2 activity is required for several types of sensory transduction including olfaction, osmosensation, mechanosensation, and chemosensation; an OCR-2 fusion protein is expressed in sensory cilia and requires the OSM-9 TRPV channel protein for proper localization; likewise, OSM-9 requires OCR-2 for its cilial localization.

Entrez ID
Symbol
GenAge
Wormbase ID

177117
osm-9
View on GenAge (osm-9)
WBGene00003889

hypothetical protein

Locus: CELE_B0212.5

Wormbase description: osm-9 encodes a TRPV channel homologous to capsaicin receptors; osm-9 is involved in sensory responses to a subset of chemical stimuli and to ASH neuron-mediated osmotic and mechanical stimuli; OSM-9 is also involved in adaptation to volatile odorants and salts; OSM-9 is expressed in a variety of sensory neurons and shows neuron-specific localization to either the cell body or the cilium.

Entrez ID
Symbol
GenAge
Wormbase ID

177943
tax-6
View on GenAge (tax-6)
WBGene00006527

Serine/threonine-protein phosphatase 2B catalytic subunit

Locus: CELE_C02F4.2

Wormbase description: tax-6 encodes an ortholog of calcineurin A that is required for inhibition and adaptation of several sensory neurons and for the normal regulation of egg-laying by serotonin; TAX-6 stimulates transcription of rcn-1, and binds RCN-1 protein if free Ca[2+] is present; in general, calcineurin positively regulates calcium-dependent signaling; tax-6 loss-of-function mutants exhibit an extended lifespan which is characterized by enhanced autophagy and dependent upon the presence of functional bec-1.

Orthologs of ocr-2;osm-9;tax-6 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Mus musculus	Trpv5;Ppp3cb
Mus musculus	Trpv5;Ppp3cc
Mus musculus	Trpv5;Ppp3ca
Mus musculus	Trpv6;Ppp3cb
Mus musculus	Trpv6;Ppp3cc
Mus musculus	Trpv6;Ppp3ca

Orthologs of ocr-2 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Mus musculus	Trpv5
Mus musculus	Trpv6

Orthologs of osm-9 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	iav

Orthologs of tax-6 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	CanA1
Drosophila melanogaster	Pp2B-14D
Drosophila melanogaster	CanA-14F
Mus musculus	Ppp3cb
Mus musculus	Ppp3cc
Mus musculus	Ppp3ca

About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.