ragc-1;skn-1

Lifespan changes: From wild type to ragc-1;skn-1

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Genetic mutants with ragc-1, skn-1 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    20

  • Diet

    NGM

  • Lifespan (days)

    20.48

  • Lifespan change (compared to wild type)

    -11.27%

  • Phenotype

    Knockdown of TORC1 pathway gene (ragc-1) failed to increase lifespan in a skn-1 mutant.

  • Lifespan comparisons

    Double mutant ragc-1(RNAi);skn-1(zu67) has a lifespan of 20.48 days, while single mutant ragc-1(RNAi) has a lifespan of 29.09 days, single mutant skn-1(zu67) has a lifespan of 20.48 days and wild type has a lifespan of 23.08 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Robida-Stubbs S et al., 2012, TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO. Cell Metab. 15(5):713-24 PubMed 22560223 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    20

  • Diet

    NGM

  • Lifespan (days)

    21.61

  • Lifespan change (compared to wild type)

    -4.68%

  • Phenotype

    Knockdown of TORC1 pathway gene (ragc-1) failed to increase lifespan in a skn-1 mutant.

  • Lifespan comparisons

    Double mutant ragc-1(RNAi);skn-1(zu67) has a lifespan of 21.61 days, while single mutant ragc-1(RNAi) has a lifespan of 28.17 days, single mutant skn-1(zu67) has a lifespan of 20.76 days and wild type has a lifespan of 22.67 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Robida-Stubbs S et al., 2012, TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO. Cell Metab. 15(5):713-24 PubMed 22560223 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    20

  • Diet

    NGM

  • Lifespan (days)

    19.78

  • Lifespan change (compared to wild type)

    -15.61%

  • Phenotype

    Knockdown of TORC1 pathway gene (ragc-1) failed to increase lifespan in a skn-1 mutant.

  • Lifespan comparisons

    Double mutant ragc-1(RNAi);skn-1(zu67) has a lifespan of 19.78 days, while single mutant ragc-1(RNAi) has a lifespan of 29.94 days, single mutant skn-1(zu67) has a lifespan of 20.28 days and wild type has a lifespan of 23.44 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Robida-Stubbs S et al., 2012, TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO. Cell Metab. 15(5):713-24 PubMed 22560223 Click here to select all mutants from this PubMed ID in the graph

Search genes: ragc-1 skn-1
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

RAs-related GTP binding protein C homolog


Locus: CELE_Y24F12A.2


Wormbase description: none available


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Protein skinhead-1;SKiNhead


Locus: CELE_T19E7.2


Wormbase description: skn-1 encodes a bZip transcription factor orthologous to the mammalian Nrf (Nuclear factor-erythroid-related factor) transcription factors; during early embryogenesis, maternally provided SKN-1 is required for specification of the EMS blastomere, a mesendodermal precursor that gives rise to pharyngeal, muscle, and intestinal cells; later, during postembryonic development, SKN-1 functions in the p38 MAPK pathway to regulate the oxidative stress response and in parallel to DAF-16/FOXO in the DAF-2-mediated insulin/IGF-1-like signaling pathway to regulate adult lifespan; in vitro assays indicate that SKN-1 can be directly phosphorylated by the AKT-1, AKT-2, and SGK-1 kinases that lie downstream of DAF-2 in the insulin signaling pathway and in vivo experiments suggest that this phosphorylation is essential for regulation of SKN-1 nuclear accumulation and hence, transcriptional regulator activity; in the early embryo, SKN-1 is detected at highest levels in nuclei of the P1 blastomere and its descendants through the 8-cell stage of embryogenesis; later in embryogenesis, SKN-1 is observed in all hypodermal and intestinal nuclei, with reporter constructs indicating that intestinal expression begins as early as the 50-100-cell stage; in larvae and young adults, SKN-1::GFP reporters are expressed in the intestine and ASI neurons, with expression in intestinal nuclei enhanced under conditions of stress or reduced DAF-2 signaling.


Orthologs of ragc-1;skn-1 in SynergyAge
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Orthologs of ragc-1 in SynergyAge
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Orthologs of skn-1 in SynergyAge
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About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Contact
Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania
Email:

Group webpage: www.aging-research.group